After oral absorption, the main 3 metabolites to which mifepristone is transformed are the monodemethylated (RU42633), didemethylated (RU42848) and hydroxylated (RU42689) analogues of mifepristone.

Metabolites are detectable at micromolar levels in the plasma 1 hour after ingestion of mifepristone. The concentrations of the monodemethylated and hydroxylated compounds show a very similar trend to mifepristone. The didemethylated compound however, appears to gradually increase in the first 10 hours after mifepristone administration.

Progesterone Receptor Binding