Historic
 
 
 
 
In the late 1980th : discovery of the epothilones A and B by Höfle
 
1990-1995 : identification of the structure of the epothilone
 
1996 : determination of the absolute configuration of the epothilones A and B
 
1996 : total synthesis of the epothilone A by Danishefsky
 
1997 : total synthesis of the epothilone A by Nicolaou