Retrosynthetic analysis of Epothilone A according to Danishesky
The Danishefsky group made major contributions to the epothilone field, being the first to accomplish a total synthesis of both epothilones A and B.
Their strategies included :
- a macrolactonization-based process
- an elegant macroaldolisation reaction including Susuki-type couplings
- an olefin metathesis approach including a stage of macrolactonization
We will only develop here the macrolactonisation strategy.