Retrosynthetic analysis of Epothilone A according to Danishesky

      The Danishefsky group made major contributions to the epothilone field, being the first to accomplish a total synthesis of both epothilones A and B. Their strategies included :  

                - a macrolactonization-based process
                - an elegant macroaldolisation reaction including Susuki-type couplings
                - an olefin metathesis approach including a stage of macrolactonization

We will only develop here the macrolactonisation strategy.