1809: Vauquelin, a French scientist, was the first
person who observed nicotine. He noticed a volatile and alkali active product in
the tobacco juice.
1828: Isolation and
purification of nicotine by Poselt and Reimann from Heildelberg's university.
They gave its name to nicotine in honor of Jean Nicot, one of the first
persons who imported tobacco in France from
“Occidental India”, in 1560.
1843: Melsens established the empiric formula of nicotine: C10H14N2.
determined its molecular weight: 162,23 g.mol-1.
Adolf Pinner elucidated the structure of nicotine and obtained the developed structure that
is known today.
50's: First studies of the metabolism of nicotine.
1981: First enantioselective synthesis of natural (S)-nicotine.
2000: Enantioselective synthesis of (R)-nicotine.