Other Cobalt containing metalloenzymes
by M. Kobayashiand S. Shimizu, Sakayu. Eur. J. Biochem., 1999,
261(1), 1-9.
"Recent studies have provided information on the biochemistry
and bioinorganic chemistry of several proteins containing
cobalt in a form other than that in the corrin ring of vitamin
B12. To date, eight noncorrin-cobalt-containing
enzymes (methionine aminopeptidase, prolidase, nitrile
hydratase, glucose isomerase, methylmalonyl-CoA
carboxytransferase, aldehyde decarbonylase,
lysine-2,3-aminomutase, and bromoperoxidase) have been
isolated and characterized. A cobalt transporter is involved in
the metallocenter biosynthesis of the host cobalt-containing
enzyme, nitrile hydratase.." The authors also consider
that understanding the differences between cobalt and nickel
transporters might lead to drug development for gastritis and
peptic ulceration. An achievement which would alleviate much
misery and suffering. Nickel is the other metal which is
involved in methanogenisis.