Professor Thomas James Simpson

Publications (1990 - present)

 

  1. Effect of Histamine Receptor Antagonists on Immunosuppression Induced by the cis-Isomer of Urocanic Acid, M. Norval, J.W. Gilmore and T.J. Simpson, Photodermatol. Photoimmunol. Photomed., 1990, 7, 243-248.
  2. "The Chemical Degradation of Mycotoxins", A.D. Pemberton and T.J. Simpson, in "Mycotoxins and Animal Feeding Stuffs: Natural Occurrence, Toxicity and Control", eds J.E. Smith and R.S. Henderson, CRC Press Inc., 1991, 797-813.
  3. "Hybrid" Pathways for the Production of Secondary Metabolites, D.A. Hopwood, C. Khosla, M.J. Bibb, T.J. Simpson, M.A. Fernandez-Moreno, E. Martinez and F. Malpartida, in Proceedings of the Sixth International Symposium on the Genetics of Industrial Microorganisms, (GIM 90) Strasbourg, 1990, 12 pages.
  4. "Application of Stable Isotope Labelling and Multinuclear NMR to Biosynthetic Studies", T.J. Simpson in, "Isotopes in the Physical and Medical Sciences", Volume 2, "Isotopic Applications in NMR Studies", eds E. Buncel and J.R. Jones, Elsevier, 1991, 431-474.
  5. The Biosynthesis of Polyketides, T.J. Simpson, Nat. Prod. Reports, 1991, 8, 573-602.
  6. Synthetic and Mechanistic Studies on Fungal Metabolic Pathways: A Guide to Fungicide Design, T.J. Simpson, M.P. Dillon and T.M. Donovan, Pestic. Sci., 1991, 31, 539-554.
  7. The Synthesis of Isotopically Labelled N-Acetylcysteamine Thioesters Utilising a Baker’s Yeast Reduction in D2O, M.P. Dillon, T.J. Simpson and J.B. Sweeney, BioMed. Chem. Lett., 1991, 1, 223-226.
  8. Molecular Genetic Analysis Reveals a Putative Bifunctional Polyketide Cyclase/Dehydrase Gene from Streptomyces coelicolor, and a Cyclase/O-methyltransferase from Streptomyces glaucescens, D.H. Sherman, M.J. Bibb, T.J. Simpson, D. Johnson, F. Malpardita, M. Fernandez-Moreno, E. Martinez, C.R. Hutchinson and D.A. Hopwood, Tetrahedron, 1991, 47, 6029-6043.
  9. Biosynthetic Studies on Tajixanthone and Shamixanthone, Polyketide Hemiterpenoid Metabolites of Aspergillus variecolor, S.A. Ahmed, E. Bardshiri, C.R. McIntyre and T.J. Simpson, Austral. J. Chem., 1992, 45, 249-274.
  10. Structural Revision and Synthesis of LL-D253a and Related Chromanone Fungal Metabolites, I.M. Chandler, C.R. McIntyre and T.J. Simpson, J. Chem. Soc., Perkin Trans. 1, 1992, 2271-2284.
  11. Biosynthesis of LL-D253a, a Polyketide Chromanone Metabolite of Phoma pigmentivora: Incorporation of 13C, 2H and 18O Labelled Precursors, I.M. Chandler, C.R. McIntyre and T.J. Simpson, J. Chem. Soc., Perkin Trans. 1, 1992, 2285-2293.
  12. Enantioselective Synthesis of Monocerin and Fusarentin Ethers: Antifungal and Insecticidal Fungal Metabolites, M.P. Dillon, T.J. Simpson and J.B. Sweeney, Tetrahedron Lett., 1992, 33, 7569-7572.
  13. Determination by NMR Methods of the Structure and Stereochemistry of Astellatol, a New and Unusual Sesterterpene, I.H. Sadler and T.J. Simpson, Magn. Reson. Chem., 1992, 30, 518-523.
  14. Characterisation of a Monoclonal Antibody to cis-Urocanic Acid: Detection of cis-Urocanic Acid in the Serum of Irradiated Mice by Immunoassay, A.M. Moodycliffe, M. Norval, I. Kimber, and T.J. Simpson, Immunology, 1993,79, 667-672
  15. The Role of Histamine-like Receptors in Immunosuppression of Delayed Hypersensitivity Induced by cis-Urocanic Acid, J.W. Gilmore, M. Norval and T.J. Simpson, Photodermatol. Photoimmunol. Photomed., 1993, 10, 273-277.
  16. Biosynthesis of Colletodiol and Related Polyketide Macrodiolides in Cytospora sp ATCC 20502: Synthesis and Metabolism of Advanced Intermediates, J.A. O’Neill, T.J. Simpson and C.L. Willis, J. Chem. Soc., Chem. Commun., 1993, 738-740.
  17. Structures of Bartanol and Iso-bartanol, Novel Macrodiolide Metabolites from Cytospora sp ATCC 20502, K.Hanson, J.A. O’Neill, T.J. Simpson and C.L. Willis, J. Chem. Soc., Perkin Trans. 1, 1994, 2493-2497.
  18. Biosynthesis of Astellatol, a Novel Rearranged Sesterterpenoid Metabolite of Aspergillus variecolor, T.J. Simpson, J. Chem. Soc., Perkin Trans. 1, 1994, 3055-3056.
  19. A Simple Enantioselective Synthesis of g-Valerolactone, J.A. O'Neill, S.D. Lindell, T.J. Simpson and C.L Willis, Tetrahedron Asymmetry, 1994, 5, 117-118.
  20. Synthesis of Early, Intermediate and Advanced Precursors for Studies of Polyketide Biosynthesis, T.J. Simpson, in "Synthesis and Applications of Isotopically Labelled Compounds", eds. J. Allen and R. Vosges, Wiley, 1995, 855-862.
  21. Polyketide Biosynthesis, T.J. Simpson, Chem. Ind., 1995, 407-411.
  22. Polyketide Synthase Acyl Carrier Proteins from Streptomyces: Expression in Escherichia coli, Purification and Partial Characterisation, J. Crosby, D.H. Sherman, M. Bibb, T.J. Simpson and D.A. Hopwood, Biochim. Biophys. Acta, 1995, 1251, 32-40.
  23. Synthesis of b-Keto and ab-Unsaturated N-Acetylcysteamine Thioesters, I.H. Gilbert, M. Ginty, J.A. O'Neill, T.J. Simpson, J. Staunton and C.L. Willis, BioMed. Chem. Lett., 1995, 5, 1587-1590.
  24. Studies on the Stereoselectivity of the Osmylation of cis-Bicyclo[3.3.0]oct-6-enes, N. Broome, P.J. O'Hanlon, T.J. Simpson, R. Stephen and C.L. Willis, J. Chem. Soc., Perkin Trans. 1, 1995, 3067-3072.
  25. Enantioselective Synthesis of the 13-Membered Macrodiolide Bartanol, J.A. O'Neill, S.D. Lindell, T.J. Simpson and C.L. Willis, J. Chem. Soc., Perkin Trans. 1, 1996, 637-644.
  26. Biosynthesis of Norsolorinic Acid and Averufin: Substrate Specificity of Norsolorinic Acid Synthase, D.S.J. McKeown, C. McNicholas, T.J. Simpson and N.J. Willett, J. Chem. Soc., Chem. Commun., 1996, 301-302.
  27. Conserved Secondary Structure in the Actinorhodin Polyketide Synthase Acyl Carrier Protein from Streptomyces coelicolor A3(2),and the Fatty Acid Synthase Acyl Carrier Protein from Escherichia coli, M.P. Crump, J. Crosby, C.E. Dempsey, M. Murray, D.A. Hopwood and T.J. Simpson, FEBS Letters, 1996, 391, 302-306.
  28. Enantioselective Synthesis of Fusarentin Methyl Ethers: Insecticidal Metabolites of Fusarium larvarum, C. McNicholas, T.J. Simpson and N.J. Willett, Tetrahedron Lett., 1996, 37, 8053-8056.
  29. Enzymatic and Chemical Methods for the Enantioselective Synthesis of Isotopically Labelled Amino Acids and Metabolic Intermediates, T.J. Simpson and C.L. Willis, Proceedings of the Chiral Europe '96 Symposium, Strasbourg, 1996, pp 49-55.
  30. Biosynthesis of Polyketide-Terpenoid (Meroterpenoid) Metabolites Andibenin B and Andilesin A in Aspergillus variecolor, T.J. Simpson, S.A. Ahmed, C.R. McIntyre, F.E. Scott and I.H. Sadler, Tetrahedron, 1997, 53, 4013-4034.
  31. The Solution Structure of the Actinorhodin Polyketide Synthase Acyl Carrier Protein from Streptomyces coelicolor A3(2), M.P. Crump, J. Crosby, C.E. Dempsey, J.A. Parkinson, M. Murray, D.A. Hopwood and T.J. Simpson, Biochemistry, 1997, 36, 6000-6008.
  32. Cochliobolic Acid, a Novel Metabolite Produced by Cochliobolus lunatus, Inhibits Binding of TGF-alpha to the EGF Receptor in a SPA Assay, N. Robinson, T.M. Gibson, M.I. Chicarelli-Robinson, L. Cameron, P.J. Hylands, D. Wilkinson and T.J. Simpson, J. Nat. Prod., 1997, 60, 6-8.
  33. Post-Translational Modification of Heterologously Expressed Streptomyces Type II Polyketide Synthase Acyl Carrier Proteins, R.J. Cox, T.S. Hitchman, K.J. Byrom, S.C. Findlow, J.A. Tanner, J. Crosby and T.J. Simpson, FEBS Letters, 1997, 405, 267-273.
  34. Enantioselective synthesis of a Putative Hexaketide Intermediate in the Biosynthesis of the Squalestatins, T.J. Simpson, R.W. Smith, S.M.Westaway, C.L. Willis, A.D. Buss, R.J.P. Cannell, M.J. Dawson and B.A.M. Rudd, Tetrahedron Lett., 1997, 38, 5367-5370.
  35. Biosynthesis of Xenovulene A®: Formation of a Cyclopentenone via a Unique Ring Expansion-Ring Contraction Mechanism, M.E. Raggatt, T.J. Simpson and M.I. Chicarelli-Robinson, Chem. Commun., 1997, 2245-2246.
  36. Applications of Isotopic Methods to Secondary Metabolic Pathways, T.J. Simpson in "Topics in Current Chemistry", Vol 195 "Biosynthesis - Polyketides and Vitamins", eds F.J. Leeper and J.C. Vederas, Springer-Verlag, Berlin, 1997, pp 1-48.
  37. Catalytic Self-Acylation of Type II Polyketide Synthase Acyl Carrier Proteins, T.S. Hitchman, J. Crosby, K.J. Byrom, R.J. Cox and T.J. Simpson, Chem. Biol., 1998, 5, 35-47.
  38. Plant Polyketide Synthases: a Chalcone Synthase-Type Enzyme which Performs a Specific Condensation Reaction with Methylmalonyl-CoA in the Biosynthesis of C-Methylated Chalcones, J. Schröder, S. Raiker, T. Berger, J. Schmidt, A.M. Soares-Sello, E. Bardshiri, D. Strack, T.J. Simpson, M. Veit and G. Schröder, Biochemistry, 1998, 37, 8417-8425.
  39. Acylation of Streptomyces Type II Polyketide Synthase Acyl Carrier Proteins, J. Crosby, K.J. Byrom, T.S. Hitchman, R.J. Cox, M.P. Crump. I.S.C. Findlow, M.J. Bibb and T.J. Simpson, FEBS Letters, 1998, 433, 132-138.
  40. MCAT is not Required for In Vitro Polyketide Synthesis in a Minimal Actinorhodin Polyketide Synthase from Streptomyces coelicolor, A.-L. Matharu, R.J. Cox, J. Crosby, K.J. Byrom and T.J. Simpson, Chem. Biol., 1998, 5, 699-711.
  41. Walleminol and Walleminone, Novel Caryophyllenes from the Toxigenic Fungus Wallemia sebi, M. Frank, J.C. Jeffery, E. Kingston, M.O. Moss, M. Murray, T.J. Simpson and A. Sutherland, Tetrahedron Lett., 1999, 40, 133-136.
  42. Biosynthesis of XR587 (Streptopyrrole) in Streptomyces rimosus Involves a Novel Carbon-to-Nitrogen Rearrangement of a Proline-Derived Unit, M.E. Raggatt, T.J. Simpson and S.K. Wrigley, Chem. Commun., 1999, 1039-1040.
  43. Ketosynthase Domain Probes Identify Two Subclasses of Fungal Polyketide Synthase Genes, L.E.H. Bingle, T.J. Simpson and C.M. Lazarus, Fungal Genetics and Biology, 1999, 26, 209-223.
  44. A Chain Initiation Factor Common to Both Modular and Aromatic Polyketide Synthases, C. Bisang, P.F. Long, J. Cortes, J. Westcott, J. Crosby, R.J. Cox, T.J. Simpson, J. Staunton and P.F. Leadlay, Nature, 1999, in press.