This course consists of six lectures and is given jointly with Dr Guy Lloyd-Jones
Each lecture provides insight into the state of the art.
Lectures by Dr Wyatt
What ortho-lithiation is and the functional groups that allow its exploitation are discussed. The method is illustrated with retrosyntheses and strategic disconnections. Topics include regioselection and anionic Fries rearrangements.
A brief history of the recent development of this methodology is presented. Its application to simple and more complicated syntheses is discussed. Topics include reagent funtion & conditions, guidelines for conjugated systems and polyhydroxylation.
The use of lithium amide bases, lithium amide nucleophiles and sparteine are highlighted. An overview of the types of reaction and where they can be used is given and their application to fundamental as well as advanced asymmetric strategy is discussed. Topics include enantioselective alpha- and beta-deprotonation of expoxides, kinetic resolution and regiodivergent resolution.
Lectures Four, Five and Six are by Dr Lloyd-Jones. These three lectures are on Transition metal catalysed reactions.