Enzyme
Structure determination
Dr Matt Crump - E-mail matt.crump@bristol.ac.uk
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Chemical shifts table A list of chemical shifts
for reference as requested - will include in handout 1 in future years Lecture
1 - Introduction to NMR for structure determination - full version uploaded - 7th December 2011 - contains some of my boardwork from
the lecture Lecture
1 Handout A compressed version of the slides - personally I would annotate handouts or make separate notes rather than printing all of the actual lecture slides Lecture
1 Notes - Notes for lecture 1 Additional Notes This explains in more detail and in a conversational way
what happens at an atomic level when we put spins into a magnetic field. I would recommend reading this.
Lecture
2 - Applications of 1D NMR and introduction of 2D NMR based assignment Lecture
2 Handout Compressed version of the slides to save trees.... Lecture
3 - TOCSY, NOESY and sequential assignment of a protein Lecture
4 - December 16th 2011 The generation of a Protein Structure plus 15N labeling for larger proteins Lecture 5 - New assignment strategies based on 13C and 15N
labeling.. Application to large proteins. SAR by NMR in drug discovery |
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