200-250 mg (2.9
mg/kg in a 70 kg man) every 4 hours, solution and tablets available.
red blood cell coune (anemia);
muscle soreness and inflammation (myopathy);
of liver function;
Can be taken
with or without food, take with to minimse stomach discomfort
Drugs that could
interfere with renal excretion or hepatic blood flow may decrease
AZT clearance and increase risk of toxicity. Drugs that are cytotoxic,
nephrotoxic or myelosuppressive should be used with caution during
AZT therapy since they may increase toxicity.
Fluconazole appears to interfere with the metabolism and clearance
of AZT, it has been suggested that patients receiving concomitant
AZT and fluconazole therapy be monitored closely.
Probenecid may produce substantially higher and prolonged serum
concentrations of AZT
APAP or ibuprofen can both be used short term, as long as the patient
is monitored closely.