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Vitamin D
Chemical Structures
Food Sources
Vitamin D in the Body
Stability
Synthesis

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Vitamin D Crystals
Vitamin D Crystals
Copied without permission from Roche Product Information

Vitamin D

Vitamin D, or calciferol, is the general name for a collection of steroid-like substances including vitamin D2, ergocalciferol (fig.1) and vitamin D3, cholecalciferol (fig.2). Found only in animal sources, vitamin D is fat soluble and can be manufactured by the body on exposure to UV radiation.

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Chemical Structures

The Chemical Structure of Vitamin D2

Fig.1 The Chemical Structure of Vitamin D2 (Ergocalciferol)
3D Structure of Vitamin D2

The Chemical Structure of Vitamin D3

Fig.2 The Chemical Structure of Vitamin D3

calcidiol

Fig.3 The Chemical Structure of Calcidiol

calcitriol

Fig.4 The Chemical Structure of Calcitriol

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Principal Sources in Food

Vitamin D is only found naturally in animals and animal products; fruit and nuts contain no vitamin D at all. Richest sources include:
  • Fish liver oils, particularly those of:
    • Halibut
    • Cod
  • Saltwater fish, including:
    • Herring
    • Mackerel
    • Salmon
    • Sardines
    • Eel
Other sources of Vitamin D are:
  • Milk
  • Butter
  • Cheese
  • Margarine
  • Cream
  • Yoghurt
  • Egg


Did You Know? In many countries, products such as milk, margarine and vegetable oil are fortified with vitamin D, and provide a significant dietary source of the vitamin.

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Vitamin D in the Body

In the body, the vitamin D is converted to its active hormone form by the liver and the kidney. The calciferol is converted to 25-hydroxycholecalciferol, calcidiol (fig.3), and then metabolized by the kidney to several active forms including 1,25-dihydroxycholecalciferol, calcitriol (fig.4).

The main function of vitamin D in the body is to maintain blood levels of calcium and phosophorus. Vitamin D is essential for the absorption of these substances from the small intestine, and also for the mineralization process of the bones. The result of vitamin D deficiency is rachitis (rickets) in children and osteomalacia in adults.

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Stability

As one of the fat soluble vitamins, vitamin D is stable in food storage, cooking and processing.

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Synthesis

Cholecalciferol is manufactured by irradiating 7-dehydrocholesterol with ultraviolet light. The production of ergocalciferol is similar, using a starting product of ergosterol, a yeast extract.

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