The Lloyd-Jones Research Group

The Interaction of Two Chiral Ligands
About a Transition Metal Centre

We recently reported the high yelding preparation (>97%) of a homochiral bis-heterodonor Nickel complex. This complex is shown above (on the right hand side) together with the disfavoured heterochiral form. We are currently studying the "match" and "mismatch" in the complexation reaction and hope to be able to use this or similar processes to resolve axially chiral ligands and also prepare ligands that are formaly derived from "unnatural" amino acids.

References:

• "Nickel (II) Complexes Bearing Phosphinoaryl Oxazoline Ligands as Pro-catalysts for Grignard Cross-coupling", Guy C. Lloyd-Jones and Craig P. Butts, Tetrahedron, 54, 901-914, 1998.
• "Perfect Complimentarity in the Fitting of Two Homochiral Heterodonor Ligands about a Nickel(II) Centre: an 'Intramolecular Embrace'", Katherine L. Bray, Craig P. Butts, Guy C. Lloyd-Jones and Martin Murray, Dalton Transactions, 1998, 1421-1422.

This project is being funded by: A Young Organic Chemists Award (1997 - 1999) from the Zeneca Strategic Research Fund and the EPSRC (Quota award).

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