Professor Thomas James Simpson

Publications (1995 – present)

1.	Synthesis of Early, Intermediate and Advanced Precursors for Studies of Polyketide Biosynthesis, T.J. Simpson, in "Synthesis and Applications of Isotopically Labelled Compounds", eds. J. Allen and R. Vosges, Wiley, 1995, 855-862.
2.	Polyketide Biosynthesis, T.J. Simpson, Chem. Ind., 1995, 407-411.
3.	Polyketide Synthase Acyl Carrier Proteins from Streptomyces: Expression in Escherichia coli, Purification and Partial Characterisation, J. Crosby, D.H. Sherman, M. Bibb, T.J. Simpson and D.A. Hopwood, Biochim. Biophys. Acta, 1995, 1251, 32-40.
4.	Synthesis of b-Keto and ab-Unsaturated N-Acetylcysteamine Thioesters, I.H. Gilbert, M. Ginty, J.A. O'Neill, T.J. Simpson, J. Staunton and C.L. Willis, BioMed. Chem. Lett., 1995, 5, 1587-1590.
5.	Studies on the Stereoselectivity of the Osmylation of cis-Bicyclo[3.3.0]oct-6-enes, N. Broome, P.J. O'Hanlon, T.J. Simpson, R. Stephen and C.L. Willis, J. Chem. Soc., Perkin Trans. 1, 1995, 3067-3072.
6.	Enantioselective Synthesis of the 13-Membered Macrodiolide Bartanol, J.A. O'Neill, S.D. Lindell, T.J. Simpson and C.L. Willis, J. Chem. Soc., Perkin Trans. 1, 1996, 637-644.
7.	Biosynthesis of Norsolorinic Acid and Averufin: Substrate Specificity of Norsolorinic Acid Synthase, D.S.J. McKeown, C. McNicholas, T.J. Simpson and N.J. Willett, J. Chem. Soc., Chem. Commun., 1996, 301-302.
8.	Conserved Secondary Structure in the Actinorhodin Polyketide Synthase Acyl Carrier Protein from Streptomyces coelicolor A3(2),and the Fatty Acid Synthase Acyl Carrier Protein from Escherichia coli, M.P. Crump, J. Crosby, C.E. Dempsey, M. Murray, D.A. Hopwood and T.J. Simpson, FEBS Letters, 1996, 391, 302-306.
9.	Enantioselective Synthesis of Fusarentin Methyl Ethers: Insecticidal Metabolites of Fusarium larvarum, C. McNicholas, T.J. Simpson and N.J. Willett,Tetrahedron Lett., 1996, 37, 8053-8056.
10.	Enzymatic and Chemical Methods for the Enantioselective Synthesis of Isotopically Labelled Amino Acids and Metabolic Intermediates, T.J. Simpson and C.L. Willis, Proceedings of the Chiral Europe '96 Symposium, Strasbourg, 1996, pp 49-55.
11.	Biosynthesis of Polyketide-Terpenoid (Meroterpenoid) Metabolites Andibenin B and Andilesin A in Aspergillus variecolor, T.J. Simpson, S.A. Ahmed, C.R. McIntyre, F.E. Scott and I.H. Sadler, Tetrahedron, 1997, 53, 4013-4034.
12.	The Solution Structure of the Actinorhodin Polyketide Synthase Acyl Carrier Protein from Streptomyces coelicolor A3(2), M.P. Crump, J. Crosby, C.E. Dempsey, J.A. Parkinson, M. Murray, D.A. Hopwood and T.J. Simpson, Biochemistry, 1997, 36, 6000-6008.
13.	Cochliobolic Acid, a Novel Metabolite Produced by Cochliobolus lunatus, Inhibits Binding of TGF-alpha to the EGF Receptor in a SPA Assay, N. Robinson, T.M. Gibson, M.I. Chicarelli-Robinson, L. Cameron, P.J. Hylands, D. Wilkinson and T.J. Simpson, J. Nat. Prod., 1997, 60, 6-8.
14.	Post-Translational Modification of Heterologously Expressed Streptomyces Type II Polyketide Synthase Acyl Carrier Proteins, R.J. Cox, T.S. Hitchman, K.J. Byrom, S.C. Findlow, J.A. Tanner, J. Crosby and T.J. Simpson, FEBS Letters, 1997, 405, 267-273.
15.	Enantioselective synthesis of a Putative Hexaketide Intermediate in the Biosynthesis of the Squalestatins, T.J. Simpson, R.W. Smith, S.M.Westaway, C.L. Willis, A.D. Buss, R.J.P. Cannell, M.J. Dawson and B.A.M. Rudd, Tetrahedron Lett., 1997, 38, 5367-5370.
16.	Biosynthesis of Xenovulene A^®: Formation of a Cyclopentenone via a Unique Ring Expansion-Ring Contraction Mechanism, M.E. Raggatt, T.J. Simpson and M.I. Chicarelli-Robinson, Chem. Commun., 1997, 2245-2246.
17.	Applications of Isotopic Methods to Secondary Metabolic Pathways, T.J. Simpson in "Topics in Current Chemistry", Vol 195 "Biosynthesis - Polyketides and Vitamins", eds F.J. Leeper and J.C. Vederas, Springer-Verlag, Berlin, 1997, pp 1-48.
18.	Catalytic Self-Acylation of Type II Polyketide Synthase Acyl Carrier Proteins, T.S. Hitchman, J. Crosby, K.J. Byrom, R.J. Cox and T.J. Simpson, Chem. Biol., 1998, 5, 35-47.
19.	Plant Polyketide Synthases: a Chalcone Synthase-Type Enzyme which Performs a Specific Condensation Reaction with Methylmalonyl-CoA in the Biosynthesis of C-Methylated Chalcones, J. Schröder, S. Raiker, T. Berger, J. Schmidt, A.M. Soares-Sello, E. Bardshiri, D. Strack, T.J. Simpson, M. Veit and G. Schröder, Biochemistry, 1998, 37, 8417-8425.
20.	Acylation of Streptomyces Type II Polyketide Synthase Acyl Carrier Proteins, J. Crosby, K.J. Byrom, T.S. Hitchman, R.J. Cox, M.P. Crump. I.S.C. Findlow, M.J. Bibb and T.J. Simpson, FEBS Letters, 1998, 433, 132-138.
21.	MCAT is not Required for In Vitro Polyketide Synthesis in a Minimal Actinorhodin Polyketide Synthase from Streptomyces coelicolor, A.-L. Matharu, R.J. Cox, J. Crosby, K.J. Byrom and T.J. Simpson, Chem. Biol., 1998, 5, 699-711.
22.	Walleminol and Walleminone, Novel Caryophyllenes from the Toxigenic Fungus Wallemia sebi, M. Frank, J.C. Jeffery, E. Kingston, M.O. Moss, M. Murray, T.J. Simpson and A. Sutherland, Tetrahedron Lett., 1999, 40, 133-136.
23.	A General Synthesis of Homochiral ß-Hydroxy-N-acetylcysteamine Thioesters, C. Le Sann, T.J. Simpson, D.I. Smith, P. Watts and C.L. Willis, Tetrahedron Lett., 1999, 40, 4093-4096.
24.	Ketosynthase Domain Probes Identify Two Subclasses of Fungal Polyketide Synthase Genes, L.E.H. Bingle, T.J. Simpson and C.M. Lazarus, Fungal Genetics and Biology, 1999, 26, 209-223.
25.	Biosynthesis of XR587 (Streptopyrrole) in Streptomyces rimosus Involves a Novel Carbon-to-Nitrogen Rearrangement of a Proline-Derived Unit, M.E. Raggatt, T.J. Simpson and S.K. Wrigley, Chem. Commun., 1999, 1039-1040.
26.	A Chain Initiation Factor Common to Both Modular and Aromatic Polyketide Synthases, C. Bisang, P.F. Long, J. Cortés, J. Westcott, J. Crosby, A.-L. Matharu, R.J. Cox, T.J. Simpson, J. Staunton and P.F. Leadlay, Nature, 1999, 401, 502-505.
27.	Structure Elucidation and Synthesis of (4S,5S,6Z,8E)-5-hydroxydeca-6,8-dien-4-olide [S,S-Sapinofuranone B] – a Novel g-lactone Metabolite of Acremonium strictum, S. Clough, M.E. Raggatt, T.J. Simpson, C.L. Willis, A. Whiting and S.K. Wrigley, J. Chem. Soc., Perkin Trans. 1, 2000, 2475-2481.
28.	A Versatile Approach to the Total Synthesis of the Pseudomonic Acids, C. McKay, T.J. Simpson, C.L. Willis, A.K. Forrest and P.J. O'Hanlon, Chem. Commun., 2000, 1109-1110.
29.	NMR Studies of Tautomerism in the Fungal Melanin Biosynthesis Intermediate 1,3,8-Trihydroxynaphthalene, T.J. Simpson and M.K.B. Weerasooriya, J. Chem. Soc., Perkin Trans 1, 2000, 2771-2775.
30.	Solid Phase Synthesis of 4-Hydroxycinnamic Acid and its Derivatives for Potential Use in Combinatorial Chemistry: A Novel Route for the Synthesis of 4-Hydroxycinnamoyl Coenzyme A and NMDA Receptor Antagonists, B.G. McIntyre, F. Martínez Bermejo, S.K. Srivastava, S.M. Husbands, J.W. Lewis, J. Crosby and T.J. Simpson, Combinatorial Chemistry and High Throughput Screening, 2001, 4, 111-114.
31.	In Vivo and In Vitro Biosynthetic Studies: Understanding and Exploiting Natural Pathways, T.J. Simpson in “Biodiversity – New Leads for the Pharmaceutical and Agrochemical Industries”, eds. S.K. Wrigley, M.A. Hayes, R. Thomas, E.J.T. Chrystal and N. Nicholson, Royal Society of Chemistry, Cambridge, 2000, pp 233-248.
32.	Design and Utility of Oligonucleotide Probes for Fungal Polyketide Synthases, T.P. Nicholson, C.M. Lazarus, B.A.M. Rudd, M.J. Dawson, T.J. Simpson and R.J. Cox, Chem. Biol., 2001, 8, in press.
33.	The ACP Domain from the Type I Rat Fatty Acid Synthase Shows Considerable Structural and Biochemical Homology with Type II Acyl Carrier Proteins, M.A.C. Reed, M.P. Crump, M. Schweizer, J. Crosby and T.J. Simpson, FEBS Letts., submitted for publication.
34.	Synthetic and Biosynthetic Studies on Macrocyclic Dilactones, J.A. O’Neill, T.J. Simpson and C.L. Willis, in “Synthesis and Applications of Isotopes and Isotopically Labelled Compounds”, eds. U. Pleiss and R. Voges, Wiley, in press.
35.	Stereocontrolled Syntheses 2,4,5-Trisubstituted Tetrahydropyrans, E.H. Al-Mutairi, S. Crosby, J. Darzi, J.R. Harding, R.A. Hughes, C.D. King, T.J. Simpson, R.W. Smith and C.L. Willis, Chem. Commun., submitted.