During
Treatment 
Oral
Dose:
200-250 mg (2.9
mg/kg in a 70 kg man) every 4 hours, solution and tablets available.
Side
effects:
Low
red blood cell coune (anemia);
headache;
nausea;
muscle soreness and inflammation (myopathy);
weakness;
abnormalities
of liver function;
fingernail discolouration;
Can be taken
with or without food, take with to minimse stomach discomfort
Drug
interactions
Drugs that could
interfere with renal excretion or hepatic blood flow may decrease
AZT clearance and increase risk of toxicity. Drugs that are cytotoxic,
nephrotoxic or myelosuppressive should be used with caution during
AZT therapy since they may increase toxicity.
Fluconazole appears to interfere with the metabolism and clearance
of AZT, it has been suggested that patients receiving concomitant
AZT and fluconazole therapy be monitored closely.
Probenecid may produce substantially higher and prolonged serum
concentrations of AZT
APAP or ibuprofen can both be used short term, as long as the patient
is monitored closely.
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