Cæruloplasmin - the Pathology
Several diseases are associated with deficits or surpluses of copper, and
there is a lot of evidence that smaller inbalances can have affects in other
ailments - particularly heart disease. It was whilst
studying ischemia that
our attention was drawn to the copper in human blood plasma, and more
recently from an association between homocysteine, caeruloplasmin and
coronary artery vein graft failure after heart bypass operations. So what are
normal levels of copper in humans?
"Normal levels"
Normal levels of cæruloplasmin in blood plasma
are between about 20 and 40 mg/dl (11-24 µM). The adult body has 50-120 mg
of copper.
There is also a two to three fold increase in Cp levels during pregnancy, and
oral contraceptives lead to similar increases. Additionally, because it is an
acute-phase reactant and an anti-inflammatory agent there is an increase in
inflammatory disease. Quote from: Metalloprotein Research Group, Guys Hospital
Copper intake of 2-3 mg / day is usually suggested for adults. Copper is
actively transported through the intestinal wall, carried in a special
protein, ceruloplasmin, in the blood, and stored in the liver. VM.C
interferes with copper availability. Copper deficiency produces an anemia,
indistinguishable from iron deficiency. Copper plays a role in iron
absorption and mobilization. Copper, deficiency impairs the formation of
connective tissue proteins, collagen and elastin. Weak bone (osteoporosis)
and defective arterial walls are the more obvious manifestations. In animals,
copper deficiency may result in dramatic death from rupture of a major blood
vessel, or the heart itself. It is not clear that these events in human
pathology are related to copper deficiency, but suggests that cooper intake
should be carefully evaluated in patients with cardiovascular disease. Copper
deficiency also contributes to increased blood cholesterol.
nutramed.com
A medical publication in 1867 reported that, during the cholera epidemics in
Paris of 1832, 1849 and 1852, copper workers did not develop cholera. One
snippit from a fascinating article which links copper with some cancers,
cardiovascular disease, immune system function, inflammation and arthritus,
osteoporosis, DHEA (dehydroepiandrosterone), explores copper and pregnancy,
seizures, and the longevity of the French! The excellence of copper pots for
cooking is also extoled!
Skinbiology.com: Copper: Your Body's
Protective & Anti-Aging Metal
Food sources of copper (mg/100g): Oyster 7.6; Whelks 7.2; Lamb’s liver
6.0; Crab 4.8; Brewer’s yeast 3.3; Olives 1.6; Hazelnuts 1.4; Shrimps
0.8; Cod 0.6; Wholemeal bread 0.25; Peas 0.2; Non-food sources of copper
include copper pipes (especially those carrying soft water) and copper
cooking/food-processing equipment.
QuestHealthLibrary.com
A review (1991) from the ICA - the International Copper Research Association
by Prof A.G.Lewis of UBC. This examines what copper does to organisms, its
environmental sources and routes, and the relation between the chemistry of
copper and it's biological importance.
The
Biological Importance of Copper: 395K Adobe pdf Download
"Abnormal levels"
Copper deficiency is associated with fetal prematurity, malnutrition,
malabsorption, chronic diarrhea, and hyperalimentation with mineral-deficient
infusates. In early copper deficiency, neutropenia and hypochromic anemias
may be seen. Additionally, patients may exhibit bone and joint abnormalities
associated with defects in collagen cross-linking (e.g., osteoporosis),
decreased skin pigmentation, and neurological abnormalities (e.g., hypotonia,
apnea, psychomotor retardation). Studies have also indicated an association
with subclinical copper deficiency and coronary heart disease.
Copper and Copper-Ceruloplasmin Index