seem tense I was going to offer you a sedative [squirts the
You're joking right?
No I'm not
Is that tartar sauce on your shoulder?
Tartar sauce? [Looks in the mirror]
[Injects Greg in the neck]
been injected with a highly concetrated dose of sodium
Street name truth serum. You will have no recollection of this in a few minutes, and tonight
for the first time in your life my friend, you are going to be honest.
U.K. CERTIFICATE: 12A
RUNNING TIME: 115
SYNOPSIS: Greg Focker (Ben Stiller)
is injected with sodium pentothal by his father-in-law Jack Byrnes
(Robert De Niro).
lies within that dart, just begging to course its way through your veins, is a
potent and quite infallible truth serum. I call it “The Undisputed Truth.”
Twice as strong as sodium pentathol, with none of the druggie
after-effect. Oh, except for a slight wave of euphoria. Can you feel it? (Kill Bill: Vol. 2)
Ernest H. Volwiler and Donalee L. Tabern, working for Abbott Laboratories,
discovered Sodium thiopental in the early 1930s. Dr. Ralph M. Waters first used
it in human beings on March 8, 1934. The investigation centred on its
properties, which were discovered to be short-term anesthesia, but surprisingly
Effect: This short-acting barbiturate is fat-soluble and
acts very quickly within the body. Once injected with sodium pentathol and
asked to count backwards from 100, the patient is most likely to forget
counting past 95.
Lethal injection: In combination with pancuronium bromide and potassium
chloride, sodium pentathol is used in certain U.S. states of the to execute
prisoners on death row via lethal injection. A high overdose is administered
which places the victim into a rapidly induced coma.
Click on the picture above
with the 3D model of the
Sodium Pentothal structure
Name: Sodium thiopental
Name: Sodium 5 - ethyl - 6 - oxo - 5 - pentan
- 2 - yl - 2 - sulfanylidene - pyrimidin - 4 - olate
What did they give you?
Sodium amytal, or some other truth agent.
Is it working?
Ask me a question I would normally lie to Helen: Are we going to die?
U.K. CERTIFICATE: 15
RUNNING TIME: 144 mins
Harry Tasker (Arnold Schwarzenegger), is
captured along with his wife Helen Tasker (Jamie Lee Curtis), and is subjected
to sodium amytal.
What about sweating Lecter?
Graham: We tried sodium amytal on him three years ago to find where he
buried a Princeton student; he gave them a recipe for dip. (Red Dragon)
Properties: White crystalline powder with no odour and
a faint bitter
taste. Sodium amytal is a drug that contains the active ingredient amobarbital
(formerly known as amylobarbitone), which is a
barbiturate derivative. It possesses hypnotic and analgesic properties.
Pharmacological Action: Sodium amytal works by
activating GABA-A receptors, thus in turn decreasing input resistance and reducing
tonic firing in neurons, while simultaneously increasing burst duration of
nerve impulses along with mean conductance at chloride (Cl-) ion
channels. As a result the decay time and relative amplitude of inhibitory
postsynaptic impulses are increased.
Name: Sodium Amobarbital
Name: Sodium 5 - ethyl - 5 - (3 - methylbutyl) -
4, 6 - dioxo - 1H - pyrimidin - 2 - olate
Barbiturates are a class of
drugs that act on GABA-A protein receptors within the CNS (brain and spinal
cord). GABA-A is a multimeric trans-membrane receptor consisting of 5 subunits
positioned around a central channel (pore). This receptor sits in the neuron
membrane at a synapse. Barbiturates bind to the receptor with a high
affinity (overdose can be lethal); once bound the GABA-A receptor it changes
conformation opening its pore allowing the influx of Cl- ions.
This hyperpolarizes the cell, which in turn inhibits the action of the receptor. Barbituratespossesses anaesthetic, sedative, and hypnotic
Click on the picture above
to view the protein structure (-helices
and -strands) of the GABA-A receptor
Truth serums are intravenous
sedatives that are injected in small doses. They make the patient woozy, with
the hypnotizing effect impairing judgment and higher brain functions.
This may cause the victim to respond to any request given during an
However truth serums cannot be relied upon 100%
patients have been known to make false statements while under treatment, as the
patient under the influence of the drug can sometimes confuse fact with fantasy.