UBIQUITIN

Structure

Primary structure [33,37]:

 

(The sequence of amino acids that make up a protein)

 

a). Human Ubiquitin:

 

Met¹-Gln²-Ile³-Phe⁴-Val⁵-Lys⁶-Thr⁷-Leu⁸-Thr⁹-Gly¹⁰-Lys¹¹-Thr¹²-Ile¹³-Thr¹⁴-Leu¹⁵-Glu¹⁶-Val¹⁷-Glu¹⁸-Pro¹⁹-Ser²⁰-Asp²¹-Thr²²-Ile²³-Glu²⁴-Asn²⁵-Val²⁶-Lys²⁷-Ala²⁸-Lys²⁹-Ile³⁰-Gln³¹-Asp³²-Lys³³-Glu³⁴-Gly³⁵-Ile³⁶-Pro³⁷-Pro³⁸-Asp³⁹-Gln⁴⁰-Gln⁴¹-Arg⁴²-Leu⁴³-Ile⁴⁴-Phe⁴⁵-Ala⁴⁶-Gly⁴⁷-Lys⁴⁸-Gln⁴⁹-Leu⁵⁰-Glu⁵¹-Asp⁵²-Gly⁵³-Arg⁵⁴-Thr⁵⁵-Leu⁵⁶-Ser⁵⁷-Asp⁵⁸-Tyr⁵⁹-Asn⁶⁰-Ile⁶¹-Gln⁶²-Lys⁶³-Glu⁶⁴-Ser⁶⁵-Thr⁶⁶-Leu⁶⁷-His⁶⁸-Leu⁶⁹-Val⁷⁰-Leu⁷¹-Arg⁷²-Leu⁷³-Arg⁷⁴-Gly⁷⁵-Gly⁷⁶

 

b). Yeast Ubiquitin:

 

Met¹-Gln²-Ile³-Phe⁴-Val⁵-Lys⁶-Thr⁷-Leu⁸-Thr⁹-Gly¹⁰-Lys¹¹-Thr¹²-Ile¹³-Thr¹⁴-Leu¹⁵-Glu¹⁶-Val¹⁷-Glu¹⁸-Ser¹⁹-Ser²⁰-Asp²¹-Thr²²-Ile²³-Asp²⁴-Asn²⁵-Val²⁶-Lys²⁷-Ser²⁸-Lys²⁹-Ile³⁰-Gln³¹-Asp³²-Lys³³-Glu³⁴-Gly³⁵-Ile³⁶-Pro³⁷-Pro³⁸-Asp³⁹-Gln⁴⁰-Gln⁴¹-Arg⁴²-Leu⁴³-Ile⁴⁴-Phe⁴⁵-Ala⁴⁶-Gly⁴⁷-Lys⁴⁸-Gln⁴⁹-Leu⁵⁰-Glu⁵¹-Asp⁵²-Gly⁵³-Arg⁵⁴-Thr⁵⁵-Leu⁵⁶-Ser⁵⁷-Asp⁵⁸-Tyr⁵⁹-Asn⁶⁰-Ile⁶¹-Gln⁶²-Lys⁶³-Glu⁶⁴-Ser⁶⁵-Thr⁶⁶-Leu⁶⁷-His⁶⁸-Leu⁶⁹-Val⁷⁰-Leu⁷¹-Arg⁷²-Leu⁷³-Arg⁷⁴-Gly⁷⁵-Gly⁷⁶

 

 

c). Barley Ubiquitin:

 

Met¹-Gln²-Ile³-Phe⁴-Val⁵-Lys⁶-Thr⁷-Leu⁸-Thr⁹-Gly¹⁰-Lys¹¹-Thr¹²-Ile¹³-Thr¹⁴-Leu¹⁵-Glu¹⁶-Val¹⁷-Glu¹⁸-Ser¹⁹-Ser²⁰-Asp²¹-Thr²²-Ile²³-Asp²⁴-Asn²⁵-Val²⁶-Lys²⁷-Ala²⁸-Lys²⁹-Ile³⁰-Gln³¹-Asp³²-Lys³³-Glu³⁴-Gly³⁵-Ile³⁶-Pro³⁷-Pro³⁸-Asp³⁹-Gln⁴⁰-Gln⁴¹-Arg⁴²-Leu⁴³-Ile⁴⁴-Phe⁴⁵-Ala⁴⁶-Gly⁴⁷-Lys⁴⁸-Gln⁴⁹-Leu⁵⁰-Glu⁵¹-Asp⁵²-Gly⁵³-Arg⁵⁴-Thr⁵⁵-Leu⁵⁶-Ala⁵⁷-Asp⁵⁸-Tyr⁵⁹-Asn⁶⁰-Ile⁶¹-Gln⁶²-Lys⁶³-Glu⁶⁴-Ser⁶⁵-Thr⁶⁶-Leu⁶⁷-His⁶⁸-Leu⁶⁹-Val⁷⁰-Leu⁷¹-Arg⁷²-Leu⁷³-Arg⁷⁴-Gly⁷⁵-Gly⁷⁶

 

d). Oat Ubiquitin:

 

Met¹-Gln²-Ile³-Phe⁴-Val⁵-Lys⁶-Thr⁷-Leu⁸-Thr⁹-Gly¹⁰-Lys¹¹-Thr¹²-Ile¹³-Thr¹⁴-Leu¹⁵-Glu¹⁶-Val¹⁷-Glu¹⁸-Ser¹⁹-Ser²⁰-Asp²¹-Thr²²-Ile²³-Asp²⁴-Asn²⁵-Val²⁶-Lys²⁷-Ala²⁸-Lys²⁹-Ile³⁰-Gln³¹-Asp³²-Lys³³-Glu³⁴-Gly³⁵-Ile³⁶-Pro³⁷-Pro³⁸-Asp³⁹-Gln⁴⁰-Gln⁴¹-Arg⁴²-Leu⁴³-Ile⁴⁴-Phe⁴⁵-Ala⁴⁶-Gly⁴⁷-Lys⁴⁸-Gln⁴⁹-Leu⁵⁰-Glu⁵¹-Asp⁵²-Gly⁵³-Arg⁵⁴-Thr⁵⁵-Leu⁵⁶-Ala⁵⁷-Asp⁵⁸-Tyr⁵⁹-Asn⁶⁰-Ile⁶¹-Gln⁶²-Lys⁶³-Glu⁶⁴-Ser⁶⁵-Thr⁶⁶-Leu⁶⁷-His⁶⁸-Leu⁶⁹-Val⁷⁰-Leu⁷¹-Arg⁷²-Leu⁷³-Arg⁷⁴-Gly⁷⁵-Gly⁷⁶

 

 

e). Soya-bean Ubiquitin:

 

Met¹-Gln²-Ile³-Phe⁴-Val⁵-Lys⁶-Thr⁷-Leu⁸-Thr⁹-Gly¹⁰-Lys¹¹-Thr¹²-Ile¹³-Thr¹⁴-Leu¹⁵-Glu¹⁶-Val¹⁷-Glu¹⁸-Ser¹⁹-Ser²⁰-Asp²¹-Thr²²-Ile²³-Asp²⁴-Asn²⁵-Val²⁶-Lys²⁷-Ala²⁸-Lys²⁹-Ile³⁰-Gln³¹-Asp³²-Lys³³-Glu³⁴-Gly³⁵-Ile³⁶-Pro³⁷-Pro³⁸-Asp³⁹-Gln⁴⁰-Gln⁴¹-Arg⁴²-Leu⁴³-Ile⁴⁴-Phe⁴⁵-Ala⁴⁶-Gly⁴⁷-Lys⁴⁸-Gln⁴⁹-Leu⁵⁰-Glu⁵¹-Asp⁵²-Gly⁵³-Arg⁵⁴-Thr⁵⁵-Leu⁵⁶-Ala⁵⁷-Asp⁵⁸-Tyr⁵⁹-Asn⁶⁰-Ile⁶¹-Gln⁶²-Lys⁶³-Glu⁶⁴-Ser⁶⁵-Thr⁶⁶-Leu⁶⁷-His⁶⁸-Leu⁶⁹-Val⁷⁰-Leu⁷¹-Arg⁷²-Leu⁷³-Arg⁷⁴-Gly⁷⁵-Gly⁷⁶

 

 

f). Arabidopsis Ubiquitin:

 

Met¹-Gln²-Ile³-Phe⁴-Val⁵-Lys⁶-Thr⁷-Leu⁸-Thr⁹-Gly¹⁰-Lys¹¹-Thr¹²-Ile¹³-Thr¹⁴-Leu¹⁵-Glu¹⁶-Val¹⁷-Glu¹⁸-Ser¹⁹-Ser²⁰-Asp²¹-Thr²²-Ile²³-Asp²⁴-Asn²⁵-Val²⁶-Lys²⁷-Ala²⁸-Lys²⁹-Ile³⁰-Gln³¹-Asp³²-Lys³³-Glu³⁴-Gly³⁵-Ile³⁶-Pro³⁷-Pro³⁸-Asp³⁹-Gln⁴⁰-Gln⁴¹-Arg⁴²-Leu⁴³-Ile⁴⁴-Phe⁴⁵-Ala⁴⁶-Gly⁴⁷-Lys⁴⁸-Gln⁴⁹-Leu⁵⁰-Glu⁵¹-Asp⁵²-Gly⁵³-Arg⁵⁴-Thr⁵⁵-Leu⁵⁶-Ala⁵⁷-Asp⁵⁸-Tyr⁵⁹-Asn⁶⁰-Ile⁶¹-Gln⁶²-Lys⁶³-Glu⁶⁴-Ser⁶⁵-Thr⁶⁶-Leu⁶⁷-His⁶⁸-Leu⁶⁹-Val⁷⁰-Leu⁷¹-Arg⁷²-Leu⁷³-Arg⁷⁴-Gly⁷⁵-Gly⁷⁶

 

 

a). Human Ubiquitin:      MQIFVKTLTGKTITLEVEPSDTIENVKA

b). Yeast Ubiquitin:      MQIFVKTLTGKTITLEVESSDTIDNVKS

c). Barley Ubiquitin:     MQIFVKTLTGKTITLEVESSDTIDNVKA

d). Oat Ubiquitin:        MQIFVKTLTGKTITLEVESSDTIDNVKA

e). Soya-bean Ubiquitin:  MQIFVKTLTGKTITLEVESSDTIDNVKA

f). Arabidopsis Ubiquitin:MQIFVKTLTGKTITLEVESSDTIDNVKA

 

a). Human Ubiquitin:      KIQDKEGIPPDQQRLIFAGKQLEDGRTL

b). Yeast Ubiquitin:      KIQDKEGIPPDQQRLIFAGKQLEDGRTL

c). Barley Ubiquitin:     KIQDKEGIPPDQQRLIFAGKQLEDGRTL

d). Oat Ubiquitin:        KIQDKEGIPPDQQRLIFAGKQLEDGRTL

e). Soya-bean Ubiquitin:  KIQDKEGIPPDQQRLIFAGKQLEDGRTL

f). Arabidopsis Ubiquitin:KIQDKEGIPPDQQRLIFAGKQLEDGRTL

 

a). Human Ubiquitin:      SDYNIQKESTLHLVLRLRGG

b). Yeast Ubiquitin:      SDYNIQKESTLHLVLRLRGG

c). Barley Ubiquitin:     ADYNIQKESTLHLVLRLRGG

d). Oat Ubiquitin:        ADYNIQKESTLHLVLRLRGG

e). Soya-bean Ubiquitin:  ADYNIQKESTLHLVLRLRGG

f). Arabidopsis Ubiquitin:ADYNIQKESTLHLVLRLRGG

 

Green colored are the amino acids which are invariable in different organisms, red colored are those amino acids which differ in various organisms.

 

 

 

Secondary structure

 

Tertiary structure

 

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Ubiquitilation

Structure