Synthesis

      Soon after the recognition of the importance of the epothilone in the anti-cancer fight, a number of groups around the world began to pursue strategies for their total synthesis.
Therefore, we currently know various total synthesis of epothilones and numbers of analogues.
     
We report here the main synthetic strategies of the epothilone A :

                - The Danishefsky Strategies
 
                - The Nicolaou Strategies