University of Bristol

School of Chemistry

Publications


60. New Heteroannulation Reactions of N-Alkoxy Benzamides by Pd(II) Catalyzed C-H Activation; Joe W. Wrigglesworth, Brian Cox, Guy C. Lloyd-Jones, Kevin I. Booker-Milburn* Org. Lett., 2011, in print. DOI.

59. 2,2-Difunctionalization of Alkenes via Pd(II)-Catalyzed Aza-Wacker Reactions; Luke D. Elliott, Joe W. Wrigglesworth, Brian Cox, Guy C. Lloyd-Jones, Kevin I. Booker-Milburn* Org. Lett., 2011, 13, 728-731. DOI.

58. Facile Double-Lithiation of a Transient Urea: Vicarious ortho-Metalation of Aniline Derviatives. Chris. E. Houlden, Guy C. Lloyd-Jones, Kevin I. Booker-Milburn,* Org. Lett., 2010, 12, 3090-3092. DOI

57. Hindered Ureas as Masked Isocyanates: Facile Carbamoylation of Nucleophiles under Neutral Conditions. Marc Hutchby, Chris E. Houlden, J. Gair Ford, Simon N.G. Tyler, Michel R. Gangé, Guy C. Llyod-Jones, Kevin I. Booker-Milburn*, Angewandte Chemie. Int. Ed., 2009, 48, 8721-8724 DOI

56. Reaction Control in Synthetic Organic Photochemistry: Switching between [5+2] and [2+2] Modes of Cycloaddition, Claudio Roscini, Kara L. Cubbage, Malcom Berry, Andrew J. Orr-Ewing, Kevin I. Booker-Milburn*, Angewandte Chemie. Int. Ed. 200948, 8716-8720 DOI

55. First Higher-Order Photocycloaddition to a C=N Bond: 1,3-Diazepines from Maleimides
Kara L. Cubbage, Kevin I. Booker-Milburn, Andrew J. Orr-Ewing, Angewandte Chemie. Int. Ed. 2009, 48, 2514-2517
DOI

54. Room-Temperature Palladium Catalyzed C-H Activation: ortho-carbonylation of Aniline Derivatives
Chris E. Houlden, Marc Hutchby, Chris D. Bailey, J. Gair Ford, Simon N. G. Tyler, Michel R. Gagné, Guy C. Lloyd-Jones and Kevin I. Booker-Milburn*, Angewandte Chemie. Int. Ed. 2009, 48, 1830-1833
DOI

53. Distinct Reactivity of Pd(OTs)2: the Intermolecular Pd(II)-Catalyzed 1,2-Carboamination of Dienes
C. E. Houlden, C. D. Bailey, G. Ford, M. Gagné, G. C. Lloyd-Jones, K. Booker-Milburn. J. Am. Chem. Soc. 2008,130, 10066-10067
DOI

52. A Protecting Group Free Total Synthesis of (±)-Neostenine; M. Lainchbury, P. M. Taylor, W.
Dohle, P. Hirst, K. I. Booker-Milburn,* J. Org. Chem., 2008, 73, 6497
DOI

51. Product Selection via Photon Flux: Laser Specific Lactone Synthesis; C. Roscini, D. M. E.
Davies, M. Berry A. J. Orr-Ewing,* Kevin I. Booker-Milburn*; Angewandte Chemie.
Int. Ed., 2008, 47, 2283-2286.
DOI

50. Acid-Catalyzed Rearrangement of Fused Alkylideneoxetanols; P.J. Hickford, J.R. Baker, I.
Bruce, K. I. Booker-Milburn* Org. Lett., 2007, 9, 4681 -4684.
DOI

49. A chemo- and regio-selective three-component dihydropyrimidinone synthesis ; Chris D. Bailey,
Chris E. Houlden, Grégory L. J. Bar, Guy C. Lloyd-Jones and Kevin I. Booker-Milburn,*
Chem. Commun., 2007, 2932-4.
DOI

48. Actinorhodin Biosynthesis: Structural Requirements for Post-PKS Tailoring Intermediates
Revealed by Functional Analysis of ActVI-ORF1 Reductase: Itoh, T.; Taguchi, T.; Kimberley,
M. R.; Booker-Milburn, K. I.; Stephenson, G. R.; Ebizuka, Y.; Ichinose, K.* Biochemistry,
2007, 46, 8181 -8188.
DOI

47. The Intramolecular Photometathesis of Pyrroles; L. D. Elliot, M. Berry, A. J. Orr-Ewing, and K.
I. Booker-Milburn* J. Am. Chem. Soc., 2007, 129, 3078-3079.
DOI

46. Use of Temporary Tethers in the Intramolecular [2+2] Photocycloaddition Reactions of
Tetrahydrophthalimide Derivatives: A New Approach to Complex Tricyclic Lactones; Ş.
Gülten, A. Sharpe, J. R. Baker, and K. I. Booker-Milburn* Tetrahedron, 2007, 63, 3659-3671
DOI

45. Reaction Optimization and Mechanism in Maleimide [5 + 2] Photocycloaddition: A Dual
Approach Using Tunable UV Lasers and Time-Dependent DFT; D. M. E. Davies, C. Murray,
M. Berry, A. J. Orr-Ewing* and K. I. Booker-Milburn* J. Org. Chem. 2007, 72, 1449-1457.
DOI

44. Copper-catalysed meso-bislactone ring opening using Grignard and mixed triorganozinc
reagents S. Borthwick, W. Dohle, P. R. Hirst and K. I. Booker-Milburn* Tetrahedron Lett.,
2006, 47, 7205-7208.
DOI

43. A Practical Flow Reactor for Continuous Photochemical Synthesis, B. D. A. Hook, W. Dohle,
P. R. Hirst, M. Pickworth, M. B. Berry, K. I. Booker-Milburn* J. Org. Chem., 2005, 7558.
DOI

42. Pd(II)-catalyzed intermolecular 1,2-diamination of conjugated dienes; Bar, G. L. J., Lloyd-
Jones, G. C., * and Booker-Milburn, K. I.* J. Am. Chem. Soc., 2005, 127, 7308-7309.
DOI

41. Enantioselective Reduction of β-Keto-Acids Using Engineered S. coelicolor; K. I. Booker-
Milburn,* R. Gillan, M. R. Kimberley, T. Taguchi, K. Ichinose, G. R. Stephenson, Y. Ebizuka,
D. A. Hopwood, Angewandte Chemie. Int. Ed., 2005, 44, 1121.
DOI

40. Remarkably Different Structures and Reaction Mechanisms of Ketoreductases for the Opposite
Stereochemical Control in the Biosynthesis of BIQ Antibiotics, T. Taguchi, K. Kunieda, M.
Takeda-Shitaka, D. Takaya, N. Kawano, M. R. Kimberley, K. I. Booker-Milburn, G. R.
Stephenson, H. Umeyama, Y. Ebizuka, and K. Ichinose,* Bioorg. Med. Chem., 2004, 12, 5917-
5927
DOI

39. Rapid Access to Azepine-Fused Oxetanols from Alkoxy-Substituted Maleimides; K. I. Booker-
Milburn,* J. R. Baker, I. Bruce, Org. Lett., 2004; 6, 1481-1484.
DOI

38. Structure and Biosynthetic Implication of (S)-NHAB, a Novel Shunt Product, from a Disruptant
of the actVI-ORFA Gene for Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2); M.
Ozawa, T. Taguchi, T. Itoh, Y. Ebizuka, K. I. Booker-Milburn, G. R. Stephenson and K.
Ichinose* Tetrahedron, 2003, 59, 8793.

37. Ritter Type Reactions of N-Chlorosaccharin: A Method for the Electrophilic Diamination of
Alkenes, K.I. Booker-Milburn,* D. Guly, B. Cox and P.A. Procopiou Org. Lett., 2003, 3313.

36. Synthesis of the Reported Structures for Pogostol and Pogostol O-Methyl Ether: A Concise
Total Synthesis of Kessane, K. I. Booker-Milburn,* H. Jenkins and P. Mohr, Org. Lett., 2003,
5, 3309.

35. A Rapid Stereocontrolled Entry to the ABCD Tetracyclic Core of Neotuberostemonine; K. I.
Booker-Milburn,* P. Hirst, J. P. H. Charmant and L. H. J. Taylor, Angew. Chem. Int. Ed., 2003,
42, 1642.

34. New Fe(III)-Mediated Radical Cascade Reactions of Cyclopropyl Silyl Ethers; K. I. Booker-
Milburn,* J.L. Jones, G.E.M. Sibley, R. Cox, and J. Meadows, Org. Lett., 2003, 5, 1107.

33. Photochemistry of Benzotriazole: An Unprecedented Tautomer-Selective Intermolecular [2+2]
Photocycloaddition K. I. Booker-Milburn,* P. M. Wood, R. F. Dainty, A.J. White, M. W.
Urquhart, H. J. Lyon, J. P. H. Charmant, Org. Lett., 2002, 4, 1487.

32. Formal Intramolecular [5+2] Photocycloaddition Reactions of Maleimides: A Novel Approach
to the CDE Ring Skeleton of (-)-Cephalotaxine L. F. Dudin, K.I. Booker-Milburn,* C.E.
Anson, and S.D. Guile, Org. Lett., 2001, 3, 3005.

31. Intramolecular Photocycloaddition of N-Alkenyl Substituted Maleimides: A Potential Tool for
the Rapid Construction of Perhydroazaazulene Alkaloids, K.I. Booker-Milburn,* C.E. Anson,
C. Clissold, N.J. Costin, R.F. Dainty, M. Murray, D. Patel and A. Sharpe, Eur. J. Org. Chem.,
2001, 1473.

30. A New Claisen Sequence for the Synthesis of 3-Substituted-2-Oxindoles, K.I. Booker-
Milburn,* M.Fedouloff, S.J.Paknoham, J.B.Strachan, J.L. Melville and M. Voyle Tetrahedron
Lett., 2000, 39, 4657.

29. Fe(III)/Cu(II) Mediated 5- and 6-Exo Oxidative Ring Expansion/Cyclisation of Cyclopropyl
Ethers: Studies Towards Dictyol C and α-Eudesmol, K.I. Booker-Milburn,* B. Cox, M. Grady,
F. Halley, S. Marrison Tetrahedron Lett., 2000, 39, 4651.

28. Chemical Characterisation of Disruptants of S.coelicolor A3(2) actVI Genes Involved in
Actinorhodin Biosynthesis , K. Ichinose,* C. Surti, T. Taguchi, F. Malpartida, K.I. Booker-
Milburn, G. R. Stephenson, Y. Ebizuka and D.A. Hopwood, J. Antibiot., 2000, 53, 144.

27. Genetic Engineering of Streptomyces coelicolor A3(2) for the Enantioselective Reduction of
Unnatural β-Keto-Ester Substrates, C.E. Anson, M.J. Bibb, K.I. Booker-Milburn,* C. Clissold,
P.J. Haley, D. A. Hopwood, K. Ichinose, W. P. Revill, G.R. Stephenson, C.M. Surti, Angew.
Chem. Int. Ed. Engl., 2000, 39, 224.

26. Sequential Ring-Opening/Cyclisation Reactions of Bicyclo[4.2.0]oct-7-enes for the Synthesis
of Cyclooctadiene Fused Lactones: Model Studies Towards the Total Synthesis of
Pachylactone, K.I. Booker-Milburn,* F. Delgado Jiménez and A. Sharpe, Tetrahedron, 1999,
55, 5889.

25. Stereoselective Intermolecular [2+2] Photocycloaddition Reactions of Tetrahydrophthalic
Anhydride and Derivatives with Alkenols and Alkynols, K.I. Booker-Milburn,* J.K. Cowell, F.
Delgado Jiménez, A. Sharpe and A. J. White, Tetrahedron , 1999, 55, 5875.

24. Proof that the ActVI Genetic Region Of Streptomyces coelicolor A3(2) is Involved in
Stereospecific Pyran Ring Formation in the Biosynthesis of Actinorhodin, K. Ichinose,* C.
Surti, T. Taguchi, F. Malpartida, K.I. Booker-Milburn, G. R. Stephenson, Y. Ebizuka and D.A.
Hopwood, Bioorg. Med. Chem. Lett., 1999,9, 395.

23. Fe(III) Mediated Oxidative Radical Cyclisation of Cyclopropanone Acetals, K.I. Booker-
Milburn,* A. Barker, W. Brailsford, B. Cox and T.E. Mansley, Tetrahedron , 1998, 54, 15321.

22. Saturated and Partially Unsaturated Carbocycles, K. I. Booker-Milburn* and A. Sharpe, J.
Chem. Soc., Perkin Trans. 1, 1998, 983.

21. Photocycloaddition of N-4-alkenyl Substituted Unsaturated Imides, K.I. Booker-Milburn,* N.J.
Costin, R.F. Dainty, D. Patel and A. Sharpe, Tetrahedron Lett., 1998, 39, 7423.

20. Bicyclo[3.3.0]Octanone Formation by Fe(III) Mediated Ring Expansion-Transannular
Cyclisation Reactions of Cyclopropyl Ethers, K. I. Booker-Milburn* and R. Dainty,
Tetrahedron Lett., 1998, 39, 5097.

19. Diastereoselective Fe(III) Mediated Oxidative Cyclisation Reactions of Cyclopropanone
Acetals, K.I. Booker-Milburn,* A. Barker and W. Brailsford, Tetrahedron Lett., 1998, 39,
4373.

18. Azabenzocycloheptenones. Part 20. Synthesis and Utilisation of 4-Amino-1,2,3,4-Tetrahydro-
1(1H)-benzazepines, K. I. Booker-Milburn, I. R. Dunkin, F. C. Kelly, A. I. Khalaf, D. A.
Learmonth, G. R. Proctor* and D. I.C. Scopes J. Chem. Soc., Perkin Trans. 1, 1997, 3261.

17. A Concise Synthesis of 7-Desmethylasteriscanolide and the Discovery of an Unusual
Fragmentation Reaction to the Related Asteriscunolide Skeleton, K. I. Booker-Milburn,* J. K.
Cowell and L. J. Harris, Tetrahedron , 1997, 37, 12319.

16. Diastereoselective Intramolecular Photochemical [2+2] Cycloaddition Reactions of Tethered L-
(+)-Valinol Derived Tetrahydrophthalimides, K. I. Booker-Milburn,* S. Gulten and A. Sharpe,
J. Chem. Soc., Chem. Commun., 1997, 1385.

15. Iron (III) Mediated Oxidative Cyclisations of Cyclopropanone Acetals, K. I. Booker-Milburn,*
B. Cox and T. E. Mansley, J.Chem.Soc., Chem. Commun., 1996, 2577.

14. Tetrahydrophthalic Anhydride and Imide: Remarkably Efficient Partners in Photochemical
[2+2] Cycloaddition Reactions With Alkenols and Alkynols, K. I. Booker-Milburn,* J. K.
Cowell, A. Sharpe and F. Delgado Jiménez, J. Chem. Soc., Chem. Commun., 1996, 249.

13. An Intramolecular [2+2] Photocycloaddition-Fragmentation Approach Towards the Total
Synthesis of Asteriscanolide, K. I. Booker-Milburn* and J. K. Cowell, Tetrahedron Lett., 1996,
37, 735.

12. Saturated and Partially Unsaturated Carbocycles, K. I. Booker-Milburn* and A. Sharpe,
Contemp. Org. Synth., 1996, 473.

11. Iron (III) Mediated Transformations of Trimethylsilyloxy Cyclopropyl Ethers. Part 2. A New 4-
Substituted-2-Cyclohexenone Synthesis, K.I. Booker-Milburn* and D. F. Thompson,
Tetrahedron, 1995, 51, 12955.

10. Model Studies Towards the Total Synthesis of Pachylactone, K.I. Booker-Milburn,* F.
Delgado Jiménez and A. Sharpe, Synlett, 1995, 735.

9. Chapter in "Organic Functional Group Transformations - The Synthesis of Alkynyl Nitrogen
and Phosphorous Compounds" 1039-1074. K.I. Booker-Milburn, Pergamon Press (1995).

8. Iron (III) Mediated Transformations of Cyclopropyltrimethylsilyl Ethers. Part 1. Free Radical
Tandem Ring Expansion-Cyclisation Reactions For The Rapid Construction of [n.3.0] Bicyclic
Ring Systems, K. I.Booker-Milburn* and D. F. Thompson, J. Chem. Soc., Perkin Trans. 1,
1995, 2315.

7. The Generation of Double Bonds of Specific Geometry by Regioselective Addition of
Organotin Cuprates to Propargylic Ethers, P. J. Parsons,* K. I. Booker-Milburn, S. H. Brooks,
S. Martel and M. Stefinovic, Synth. Commun., 1994, 24, 2159.

6. Model Studies Towards the Total Synthesis of Asteriscanolide, K. I. Booker-Milburn,* J. K.
Cowell and L. J. Harris, Tetrahedron Lett., 1994, 35, 3883.

5. A New 4-Substituted Cyclohexenone Synthesis, K.I. Booker-Milburn* and D. F. Thompson,
Tetrahedron Lett., 1993, 34, 7291.

4. Tandem Ring Expansion-Cyclisation Reactions: Synthesis of the Bicyclo-[4.3.0]-Nonane and
Bicyclo-[6.3.0]-Undecane Ring Systems, K. I. Booker-Milburn* and D. F. Thompson, Synlett,
1993, 592.

3. Tandem Ring Expansion-Cyclisation Reactions: A Novel Method for the Rapid Construction of
the Bicyclo [5.3.0] decane Ring System, K. I. Booker-Milburn* Synlett, 1992, 809.

2. A Convenient Method for the Synthesis of C-5 Substituted 1-Tosylpyrazoles, K. I. Booker-
Milburn* Synlett, 1992, 372.

1. A Concise Synthesis of the C9C17 Fragment of the Avermectins. K. I. Booker-Milburn, G. D.
Heffernan and P. J. Parsons* J. Chem. Soc., Chem. Commun., 1992, 350




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