The molecule
Physical properties
Chemical properties
Antimicrobial properties
Structure-activity relationships
Chemical syntheses


A biosynthesis of tetracycline, particularly in its latter stages, has been studied with the use of mutant cultures. It has been established that the so-called pretetronids:

are intermediates, convertable by non-mutated Streptomyces aureofaciens into tetracyclines [6]. Cosynthesis, by use of blocked mutants, has demonstrated that 4-hydroxy-6-methylpretetranid (R1 = Me, R2 = OH) is a transformable intermediate and the precursor to the 6-methyltetracyclines [7,8]. The complete biosynthesis is as follows [9]: