Cæruloplasmin - the Pathology

caeruloplasmin with some active binding sites
Caeruloplasmin structure, with some active binding sites marked

There is an escalating list of diseases associated with copper, and since 90% of copper in blood is associated with caeruloplasmin, it has a very large role in pathology. As yet the membrane bound versions of caeruloplasmin are very ill defined.

  • Normal and Abnormal Levels
  • Aceruloplasminemia -
  • Wilson's Disease
  • MND or ALS (Lou Gehrig's Disease)
  • Menke's Disease
  • Heart Disease
  • Other Connections
  • An intriguing observation is that the structure of human caeruloplasmin (hCP) provides a model for blood clotting factor VIII, and that the protein domains of factor VIII have a considerable kinship to of those of hCP:

    the overall sequence identity between hCP and the A-domains of factor VIII is around 34%

    Zaitseva et al