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Biosynthesis
A biosynthesis of tetracycline, particularly in its latter stages, has been studied with
the use of mutant cultures. It has been established that the so-called pretetronids:
are intermediates, convertable by non-mutated Streptomyces aureofaciens into tetracyclines [6]. Cosynthesis, by use of blocked mutants, has demonstrated that 4-hydroxy-6-methylpretetranid (R1 = Me, R2 = OH) is a transformable intermediate and the precursor to the 6-methyltetracyclines [7,8]. The complete biosynthesis is as follows [9]:
