Aggarwal Group

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Publication for Alex & Tobias

December 2018
Team Strain Release

Well done to Alex and Tobias for their recent paper in Nature Chemistry! The publication details the synthesis of strained bicyclo[1.1.0]butane (BCB) boronate complexes and their addition to aryl palladium complexes; the overall process generating 1,1,3-trisubstituted cyclobutane products with perfect diastereoselectivity. Congratulations to all involved!

AF

Valerio Fasano starts

December 2018
Valerio Fasano

Valerio, who recently finished his PhD at Manchester with Mike Ingleson, has started his postdoctoral research in our group. Greetings, Valerio!

Twitter

December 2018
Twitter

The group's twitter page (@AggarwalLab) is now up and running. Feel free to follow us, using the button above, for an insight into our labs!

Lin Guo starts

November 2018
Lin Guo

We have a new postdoc, Lin, who joins us on a DFG Fellowship. Welcome, Lin!

Arthur C. Cope Scholar Award for Prof. Varinder Aggarwal

October 2018
Varinder Aggarwal

Congratulations to Varinder who has been selected to receive one of the 2019 Arthur C. Cope Scholar Awards! He will receive the award at the ACS National Meeting in San Diego in August 2019.

Masters Students Start

October 2018
David Bacos James Southon Jessica Streets

Our three masters students –David Bacos, James Southon, and Jessica Streets– have started in the group, and their projects are well underway. Good luck to you all!

Xiabing Li starts

October 2018
Xiabing Li

A visiting scholar from Shaanxi Normal University, Xiabing Li, has started in the group. Greetings, Xiabing!

Oliver Dutton starts

October 2018
Oliver Dutton

We have a new PhD student, Oliver Dutton, who will be working jointly with Craig Butts. Welcome, Olly!

Madhava Rudrakshula starts

October 2018
Madhava Rudrakshula

Madhava has started in our group as a new postdoctoral researcher. Welcome, Madhava!

Alexander Fawcett and Siying Zhong Leave

October 2018
Alex Fawcett Siying Zhong

Both Alex and Siying have finished their PhD studies in our group. Alex will be starting with John Hartwig at UC Berkeley shortly, and Siying with Alessio Ciulli at the University of Dundee. We will miss them dearly, and wish them the best of luck!

Poster Prize for Johan Pradeilles

September 2018
Johan Pradeilles

Well done to Johan who won a prize at XXII International Conference on Organic Synthesis (22-ICOS), an international symposium which took place in Florence on 16-21 September, for his poster entitled ‘Helical Hydrocarbons: Synthesis and Control of Screw-Sense’. The event included around 800 participants and 450 poster presentations.

Beatrice LeFanu Collins Leaves

September 2018
Beatrice Collins

Beatrice has finished her postdoctoral studies in our group, and will be starting her own independant career here, at the University of Bristol. We wish her all the best!

Bjoern Andreassen and Elliott Denton Leave

September 2018
Bjoern Andreassen Elliott Denton

Bjoern and Elliott have finished their Masters studies in our group. Both are going to undertake PhDs - Bjoern with David Leigh in Manchester, and Elliott with Bill Morandi in Switzerland. Good luck, guys!

Amna Murtaza Leaves

September 2018
Amna Murtaza

Amna has finished her visit here in Bristol, and is returning to her home institution, Quaid-i-Azam University, Islamabad, to finish her PhD. Good luck, Amna!

Dr. Alexander Fawcett

7th September 2018
Alex Fawcett

Alex successfully completed his defence and is now Dr. Fawcett! Congratulations, Alex!

Nils Winter starts

September 2018
Nils Winter

A new postdoctoral researcher, Nils Winter, has started in the group. Welcome, Nils!

Phil Grant Leaves

August 2018
Phil Grant

Phil has finished his visit here in Bristol, and is returning to New Zealand -after a brief trip to Portugal- to complete his PhD. Good luck with the rest of your synthesis, Phil!

Songjie Yu starts

August 2018
Songjie Yu

We welcome a new postdoctoral researcher, Songjie Yu, to the group. Greetings, Songjie!

Fellowship for Beatrice Lefanu Collins

June 2018
Beatrice Lefanu Collins

Congratulations to Beatrice who has been awarded a Royal Society University Research Fellowship for five years, starting 1st October 2018, here at Bristol University to study 'Metals and Molecular Machines: A New Approach to Autonomous Molecular-Level Motion'.

Ganesh Venkataraman Leaves

July 2018
Ganesh Venkataraman

Ganesh has finished his postdoctoral studies in our group, and has moved to Kharagpur, West Bengal, India, to start as an Assistant Professor at the Indian Institute of Technology. Good luck, Ganesh!

Poster Prize for Charlotte Gregson

3rd July 2018
Char Gregson

Well done to Charlotte who won a poster prize at the recent Early Career Researcher event entitled Celebration of Bristol Chemistry V! The event comprised of 3 talks (one from our own Dr. Mattia Silvi) and then a poster session, with over 50 competitors from the 3 different sections at Bristol.

Poster Prize for Johan Pradeilles

June 2018
Johan Pradeilles

Well done to Johan who won a poster prize at BORAM XVI, an intimate conference focused entirely around boron. As part of his prize, Johan gave a talk on his poster to the conference audience.

Dr. Giorgia Casoni

27th June 2018
Giorgia Casino

Giorgia has successfully passed her viva and is now Dr. Casoni! Congrats, Giorgia! Giorgia will be moving to Pharmaron UK Ltd in just under a month, and we wish her all the best.

Durga Prasad Hari Starts

June 2018
Durga Prasad Hari

We have had a new postdoctoral member start in the group, Hari. Welcome!

Prize for Siying Zhong

19th June 2018
Siying Zhong

Well done to Siying who won a runner-up prize at the 3rd year PhD Organic and Biological section seminar recently!

Joe Abell and Luke Lewis-Borell Start

June 2018
Joe Abell Luke Lewis-Borell

We have two new PhD students, Joe Abell and Luke Lewis-Borell, who join us from the Chemical Synthesis CDT. Welcome to both!

James Smith Leaves

June 2018
James Smith

After an impressive five years in the Aggarwal group, James Smith has finished his postdoctoral studies and is moving to Charles River Laboratories. All the best and good luck outside of Bristol, James!

Publication for Team PG

May 2018
Team PG CEJ

Congratulations to Team PG for their recent publication in Chemistry - A European Journal, which details the re-optimisation of the L-proline catalysed dimerization of succinaldehyde to a key enal intermediate. The isolated yield has been improved from 14% to 29% to deliver 12.8 g of enal, and these new conditions were used to enable the synthesis of Δ¹²‐PGJ₃, which has considerable biological potency towards stem cell cancer. Well done to all involved!

Team PG CEJ

Daniel Kaiser Starts

May 2018
Daniel Kaiser

We have a new postdoctoral member, Daniel Kaiser, who will be working on photochemistry in the group. Welcome, Daniel!

Alexander von Humboldt Sponsorship

3rd May 2018
Alexander von Humboldt Foundation

Eleven members of the group recently went to visit the Gottfried Wilhelm Leibniz Universität in Hannover, as part of Prof. Aggarwal's Humboldt Fellowship. We enjoyed fantastic talks on the first day, with diverse chemistry from all areas, and were extremely impressed by the showing from our hosts. The second day was spent with a tour of the New Town Hall and the beautiful Herrenhausen Gardens, see pictures below, in the sunshine. Thank you to all our hosts, especially Prof. Dr. Andreas Kirschning, for an excellent experience. We hope to see you all again soon!

All speakers with Prof. Kirschning and Prof. Aggarwal

The Aggarwal group

Posters prizes for Riccardo Mega and Lydia Dewis

1st May 2018
Alex Fawcett Lydia Dewis

The Aggarwal group celebrated success at the recent Organic and Biological Section Syngenta Poster Competition, with Ricky Mega winning a runner up prize and Lydia Dewis the participant prize. The judges, Dr Dave Sale (Syngenta) and Dr Sarah Barry (King's College London), were extremely impressed with the overall standard. Well done to all involved!

Bristol Synthesis Meeting

April 2018
Bristol Synthesis Meeting

The 2018 Bristol Synthesis Meeting is scheduled to take place on April 10th. Registration can be found at the School of Chemistry online shop. We are happy to present the following line up of speakers:

Please visit the event page on the School of Chemistry website for further information, or click the following link to preview a copy of the programme: pdf.

Felix Pape Starts

April 2018
Felix Pape

Felix Pape has started postdoctoral studies in our group. Felix has come from Berlin, and will be working in our group for at least one year. Welcome, Felix!

Oleksandr Zhurakovskyi Leaves

March 2018
Oleksandr Zhurakovskyi

Alex Z. has finished his postdoctoral studies in the Aggarwal group, and is leaving Bristol to start at Pharmaron in Hertfordshire. Good luck in "the real world" Alex!

Phil He Leaves

March 2018
Phil-He

Prof. Phil-He has finished his visit to our lab and has returned to his group in Shihezi University, China. All the best, Phil!

Phillip Grant Starts

March 2018
Phillip Grant

Phil has joined the group from New Zealand as a visiting PhD student for 6 months. Welcome Phil!

Prof. Aggarwal selected as Robert Robinson Lecturer in 2021

February 2018
University Of Oxford

Varinder will be the Robert Robinson Lecturer at the University of Oxford in 2020/2021. This Lectureship is the most prestigious award Oxford has to offer, and the awardee will spend several days at Oxford and deliver two research lectures.

Murat Kucukdisli Leaves

February 2018
Murat Kucukdisli

Dr. Murat Kucukdisli has finished his postdoctoral research in our lab, and is going to the Prof. Till Opatz group at the University of Mainz, Germany, to work as a senior postdoctral researcher. All the best, Murat!

Selbi Keskin Starts

February 2018
Selbi Keskin

Welcome to Selbi Keskin, who has joined our group as a postdoctoral researcher on a TUBITAK fellowship!

Updated Research Page

February 2018
Aggarwal Research

Our Research Page has been updated. Now it includes our recent work in photochemistry and other areas.

Aggarwal Group Research

Belen Rubial Starts

January 2018
Belen Rubial

Belen Rubial has joined our group as a postdoctoral researcher on a Clarin-COFUND program fellowship. Welcome to the group, Belen!

Genentech research internship for Lydia Dewis

January 2018
Lydia Dewis

Congratulations to CDT student Lydia Dewis who has been invited to Genentech in San Francisco for a 12 week research internship with Dr David Russell this summer. This is a highly competitive programme, with thousands of applications every year. Lydia will be studying structural behaviour of fluorinated drugs to further the Genentech NMR programme. Enjoy California, Lydia!

Posters prizes for Alex Fawcett and Lydia Dewis

17 January 2018
Alex Fawcett Lydia Dewis

The Aggarwal group had a combo of success at the recent RSC Organic Division South-West Regional Meeting: 3rd year student Alex Fawcett was the winner of the Poster Presentation Prize and 3rd year CDT student Lydia Dewis won a runner up prize! The meeting was held at the University of Bristol, and was attended by 40 presenters, including several distinguished plenary speakers from around the country.

Kurt Alder Lecture 2018

January 2018
University of Cologne

Prof. Aggarwal has been invited to deliver the prestigious Kurt Alder Lecture 2018 at the University of Cologne, Germany. Varinder joins a list of very distinguished previous Kurt Alder Lecturers.

α-Cyclopiazonic Acid Finished

January 2018
Angewandte Chemie International Edition 2018

Congratulations to Team CPA for finishing the total synthesis of α-cyclopiazonic acid after many years of blood, sweat, and tears. Perseverance, creativity, and methodical approach are indispensable attributes of success in organic chemistry, and this project clearly required a lot. Congrats to Alex, Yunus, Lorenz, Viji, Chun, Mike, Mark, Marco, Mushtaq, Mehrnoosh, and Johno!

Selected as Hot Paper

Enantioselective Synthesis of the Cyclopiazonic Acid Family Using Sulfur Ylides

Rafael Dias Leaves

December 2017
Rafael Dias

Dr. Rafael Dias has finished his postdoctoral visit to our lab and returned to Brazil. All the best, Rafael!

Poster Prize for Siying Zhong

4 December 2017
Siying Zhong

Congratulations to Siying Zhong who won the participant prize at the Royal Society of Chemistry Organic Division Poster Symposium! The event was held in London on Monday, 4th December, and included 40 participants including Giorgia Casoni, also from our lab.

Dr. James Smith

14 December 2017
Dr. James Smith

James Smith has successfully defended his thesis, and is now Dr. Smith. Congrats, James!

Raphael Bigler Leaves

December 2017
Raphael Bigler

Raphael Bigler, aka the "Swiss Raphi", has finished his postdoctoral work and is moving back home to Switzerland. After travelling the world to New Zealand, he will join Roche in Basel.

Andrejs Pelšs Leaves

October 2017
Andrejs Pelšs

Andrejs Pelšs, a postdoctoral researcher from Latvia, has finished his studies in our lab and moved back to Riga where he will continue as researcher. All the best, Andrejs!

Renata Calo Lapido Leaves

October 2017
Renata Calo Lapido

Renata, a visiting student from Spain, has finished her studies in our lab and returned home. All the best, Renata!

Raffael Schrof Starts

October 2017
Raffael Schrof

Raffael Schrof joined our lab as a postdoctoral researcher on a Swiss NSF fellowship. Welcome to the group, Raffael!

Amna Murtaza Starts

September 2017
Amna Murtaza

Amna Murtaza joined our lab as a visiting postgraduate student on a CSC fellowship. Welcome to the group, Amna!

Sheenagh Aiken Starts

September 2017
Sheenagh Aiken

Sheenagh Aiken joined our lab as a PhD student. Welcome to the group, Sheenagh!

Muhammad Imran Leaves

September 2017
Muhammad Imran

Dr. Muhammad Imran finished his postdoctoral stay in our lab. All the best, Imran!

Roly Armstrong Leaves

September 2017
Roly Armstrong

Dr. Roly Armstrong finished his postdoctoral stay in our lab and moved to the University of Oxford where he will work in the group of Prof. Donohoe. All the best, Roly!

Stefan Aichhorn Leaves

September 2017
Stefan Aichhorn

Dr. Stefan Aichhorn finished his postdoctoral stay in our lab and moved back to Austria. All the best, Stefan!

Cristina García Leaves

September 2017
Cristina García

Dr. Cristina García Ruiz finished her postdoctoral placement in our lab and moved back to Spain. All the best, Cristina!

Bjoern Andreassen Starts

September 2017
Bjoern Andreassen

Bjoern Andreassen has joined our group as Master's student. Welcome to the lab, Bjoern!

Christopher Sandford Leaves

September 2017
Christopher Sandford

Dr. Christopher Sandford has finished his doctorate in our lab and gone to the USA for postodoctoral studies. He will work in Prof. Sigman's group at the University of Utah. All the best, Chris!

Assembly Line Synthesis Featured in Nachrichten aus der Chemie

September 2017
Nachrichten aud der Chemie

Our research on assembly line synthesis has been featured in a German magazine, Nachrichten aus der Chemie, in the section Synthese im Blickpunkt (Synthesis in Focus). Synthese im Blickpunkt wants to stimulate the use of new synthetic procedures or elegant and important organic syntheses. This year, contributions to the series are written by Johannes Teichert, Juniorprofessor in chemistry at the TU Berlin.

Polyketides by assembly-line

Abstract
The iterative lithiation-borylation combines C-C bond formation with the selective construction of asymmetrically substituted carbon atoms. This methodology allows to build adjacent stereocentres in rapid succession.

Conclusion
The stereoselective lithiation-borylation is a good tool to generate alkyl chains with stereogenic centres. Particularly attractive is that different building blocks are obtained in a reaction sequence and simultaneously C-C bonds and stereocentres are generated. Such reactions occur in good yields and with high stereoselectivity, which compromises the stoichiometric use of metal reagents and chiral ligands as sparteine.

Chao Shu Starts

September 2017
Chao Shu

Dr. Chao Shu has joined our lab as a postdoctoral researcher. Welcome to the group, Chao!

Hannah Baars Leaves the Lab

August 2017
Hannah Baars

Dr. Hannah Baars has finished her postdoctoral studies in our lab and moved back to Germany. All the best, Hannah!

Eddie Myers Becomes Lecturer at NUI Galway

August 2017
Eddie Myers

Dr. Eddie Myers, our Research Officer in 2014-2017, moves up the academic ladder and becomes Lecturer in Organic Chemistry at NUI Galway, Ireland. We thank you for all your contributions to the Aggarwal lab and wish you the most outstanding career, Eddie!

Moritz Classen Leaves the Lab

August 2017
Moritz Classen

Visiting student Moritz Classen has finished his placement in Aggarwal lab and returned to Germany to finish his Master's studies. All the best, Moritz!

Alba Millán Delgado Leaves the Lab

August 2017
Alba Millán Delgado

Dr. Alba Millán Delgado has finished her postdoctoral stay in our lab and moved on as Juan de la Cierva Fellow to the Organic Chemistry Department at the University of Granada (Spain). We wish you all the best, Alba!

Alex Fawcett and Siying Zhong to attend J-NOST-13

August 2017
NOST

Alex Fawcett and Siying Zhong have been selected by the Royal Society of Chemistry to attend J-NOST-13 at Banaras Hindu University (BHUI) in Lucknow, India in November this year. NOST is a trust established by senior Indian organic chemists, financed by money from Indian industries and other donors, in order to organize conferences, J-NOST being specifically for PhD students. Selection is highly competitive with Alex and Siying being two of only eight students selected from across the UK. Congrats to Alex and Siying!

Alexander FawcettSiying Zhong

ACIE Review: Asymmetric Synthesis of Secondary and Tertiary Boronic Esters

August 2017
Angew. Chem. Int. Ed.

We have published a review in Angew. Chem. Int. Ed. on the asymmetric synthesis of secondary and tertiary boronic esters. Cognrats to Beatrice and Claire!

Asymmetric Synthesis of Secondary and Tertiary Boronic Esters

JACS: Homologation using Sulfinyl Benzoates

August 2017
J. Am. Chem. Soc.

We have published a JACS paper on homologation of boronic esters using α-sulfinyl benzoates via Li and Mg carbenoids. Congrats to Giorgia, Murat, James, and Matt!

α-Sulfinyl Benzoates as Precursors to Li and Mg Carbenoids for the Stereoselective Iterative Homologation of Boronic Esters

Renata Calo Lapido Starts

August 2017
Renata Calo Lapido

Renata Calo Lapido, a PhD student from the CIQUS, University of Santiago de Compostela, has joined our lab as a visitor. Welcome to the group, Renata!

Elliott Denton Starts

August 2017
Elliott Denton

Elliott Denton, a MSc by Research postgraduate student has joined the group. Welcome to the group, Elliott!

Nandakumar Meganathan Starts

August 2017
Nandakumar Meganathan

Dr. Nandakumar Meganathan, a postdoctoral researcher from India, has joined our lab as a Marie Curie Fellow. Welcome to the group, Nandakumar!

ACIE: Synthesis of Tertiary Alcohols and Thiols

August 2017
Angewandte Chemie International Edition

We have published a paper in Angew. Chem. Int. Ed. on the synthesis of tertiary alcohols and thiols using non-stabilized tertiary α-oxy- and α-thio-organolithiums. Congrats to Alex, Ana, Cinzia and Pradip!
Selected as Hot Paper in ACIE.

Asymmetric Synthesis of Tertiary Alcohols and Thiols via Non-Stabilized Tertiary α-Oxy- and α-Thio-Organolithiums

Dr. Worawat Niwetmarin

1 August 2017
Worawat Niwetmarin

Worawat Niwetmarin has successfully defended his thesis and became Dr. Niwetmarin. Congrats, Shake!

Dr. Christopher Sandford

31 June 2017
Christopher Sandford

Christopher Sandford has successfully passed his viva and became Dr. Sandford. Congrats, Chris!

Daniel Pflästerer Leaves the Lab

June 2017
Daniel Pflästerer

Dr. Daniel Pflästerer has finished his postdoctoral stay in our lab and returned to Germany. All the best, Daniel!

Nature: Synthesis of Baulamycin

July 2017
Nature

We have published in Nature on the total synthesis of baulamycin. This long and arduous project required a synergy of organic synthesis, molecular modelling and NMR studies as almost all stereocentres in the target had to be reassigned. Congrats to Jingjing, Paula, Siying, and Muhammad!
News & Views
Highlighted in C&EN
Highlighted on Phys.org
Highlighted at the University website
Highlighted in Chemistry World

Synergy of synthesis, computation and NMR reveals correct baulamycin structures

Synthesis: Review on Zweifel Olefination

July 2017
Synthesis

Our latest review has been published in Synthesis. It provides an overview of the Zweifel olefination reaction, from its origins to the most recent developments. Congrats, Roly!

50 Years of Zweifel Olefination: A Transition-Metal-Free Coupling

JACS: Markovnikov Hydroboration of Unactivated Terminal Alkenes

June 2017
J. Am. Chem. Soc.

We have published in JACS on enantioselective rhodium(III)-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. This is our second JACS paper in one week! Congrats to James, Beatrice and Matt!

Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

JACS: Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters

June 2017
J. Am. Chem. Soc.

We have published a JACS paper on enantiospecific synthesis of ortho-substituted benzylic boronic esters by a 1,2-metalate rearrangement/1,3-borotropic shift sequence. Congrats to Stefan and Rafael!

Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence

Highlighted in Angew. Chem. Int. Ed.

June 2017
Angewandte Chemie International Edition

Our JACS publication on photochemical alkylation of vinyl boronate complexes has been highlighted in the coming Angew. Chem. Int. Ed. issue. Congrats to Mattia and Chris!

ACIE: Enantiospecific sp2-sp3 Coupling

June 2017
Angewandte Chemie International Edition

Our paper on enantiospecific sp2-sp3 coupling of boronic esters with p-arylacetylenes has been accepted in Angew. Chem. Int. Ed. Congratulations, Ganesh and Marcin!

Alkynyl Moiety for Triggering 1,2-Metallate Shifts: Enantiospecific sp2-sp3 Coupling of Boronic Esters with p-Arylacetylenes

Rafael Dias Starts

June 2017
Rafael Dias

Rafael Dias, a postdoctoral researcher from Brasil, has joined our lab. Welcome to the group, Rafael!

Thesis Commendation for Maziar Mohiti

June 2017
Maziar Mohiti

PhD thesis of Maziar Mohiti (2011–2015) has been commended by the Faculty of Science of the University of Bristol. This accolade is achieved by only about 10% of the research students. Congrats, Maziar!

Tobias Biberger Leaves the Lab

June 2017
Tobias Biberger

Tobias Biberger, a visiting student from Germany, has finished his placement in Aggarwal Group and is now back in Aachen, where he will continue his Master's studies. We thank Tobias for all the hard work and lots of fun he brought. All the best, Tobias!

Science: Photoinduced Decarboxylative Borylation

June 2017
Science

We have just published our paper on the photoinduced decarboxylative borylation of carboxylic acids in Science (First Release). This new methodology links the diversity of carboxylic acids to the broad utility of boronic esters. Congratulations to Alex, Johan, Yahui and Tatsuya!

Photoinduced Decarboxylative Borylation

Prize for Alex Fawcett

June 2017
Alex Fawcett

Alex Fawcett has won a runner-up prize at the Organic and Biological Section Postgraduate Symposium held at the School of Chemistry. Congrats, Alex!

Rory Mykura Starts

May 2017
Rory Mykura

Rory Mykura, a PhD student from the CDT programme, has joined Aggarwal group. Welcome to the lab, Rory!

Another Poster Prize for Siying Zhong

May 2017
Siying Zhong

Siying Zhong won yet another poster prize! Her poster Synergy of Computation, NMR and Synthesis Reveals True Baulamycin Structure won the 1st place at the inaugural Bio-Techne Chemistry Poster Symposium. The competition included contestants from Bath, Bristol and Cardiff Universities. Impressive achievement, Siying!

Dr. Teerawut Bootwicha leaves the lab

May 2017
Teerawut Tong Bootwicha

Dr. Teerawut "Tong" Bootwicha has left the lab for Thailand where he will start as Lecturer at the Mahidol University (Bangkok). We wish you a spectacular academic career, Tong! Congrats!

Lab Leavers

May 2017

We would like to send our best wishes to the lab's recent alumni: Olivier Wagnières, Paula Lorenzo, and Ana Varela. Olivier is back to Switzerland where he joined a startup in Basel. Paula is back to Spain where she is doing a postdoc with Prof. Ángel R. de Lera and Prof. Rosana Álvarez (University of Vigo). And Ana joined the Institute of Cancer Research in London as a postdoc. Great job, everyone!

Dr. Ana Varela

19 May 2017
Ana Varela

Congratulations to Ana on successfully passing her viva and becoming Dr. Varela!

On the Cover of Chemical Communications

May 2017
Chemical Communications

Our review on the sterospecific functionalizations of boronic esters has been selected for the inside cover of Chemical Communications, Issue 40. The cover, entitled "Boron at the helm", features a famous steamship SS Great Britain, one of Bristol landmarks. Congrats to Chris!

Chemical Communications

RSC Synthetic Organic Chemistry Award for Prof. Aggarwal

May 2017
Varinder Aggarwal

Varinder has been awarded the Royal Society of Chemistry Synthetic Organic Chemistry Award for 2017. This has been given for "highly creative work in the development of new synthetic methods based on the asymmetric homologation of boronic esters and their applications in natural and non-natural product synthesis".

As part of the Award, Varinder will deliver a number of lectures across UK universities.

Poster Prize for Siying Zhong

April 2017
Siying Zhong

Second year PhD student Siying Zhong won the 1st prize at the annual Organic and Biological Section Syngenta Poster Competition for postgraduate students. Her poster was titled Synergy of Computation, NMR and Synthesis Reveals True Baulamycin Structure. Contrats, Siying!

Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling

April 2017
Org. Lett.

Our paper on the synthesis of alkenes by the transition-metal-free Zweifel couplig is out. Congratulations to Roly and Shake!

Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling

Conjunctive Functionalization of Vinyl Boronate Complexes

April 2017
Chemical Communications

We have published a paper on functionalisation of vinyl boronates into useful products, using a diastereoselective three-component coupling. Congrats to Roly, Chris, and Cristina!

Conjunctive functionalization of vinyl boronate complexes with electrophiles: a diastereoselective three-component coupling

Merging Photoredox with 1,2-Metallate Rearrangements

April 2017
J. Am. Chem. Soc.

We have published a JACS paper on photochemical alkylation of vinyl boronate complexes. Congrats to Mattia and Chris!

Merging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes

Stereoselective Synthesis of Polypropionates

April 2017
Nature Chemistry

Our Nature Chemistry paper on the application of assembly-line synthesis towards polypropionates is out! Congrats to Tong and Julian!

Iterative assembly line synthesis of polypropionates with full stereocontrol

Review on Boron Functionalization

April 2017
Chemical Communications

Our group has published a feature article in Chemical Communications on stereospecific functionalizations and transformations of secondary and tertiary boronic esters. Congrats, Chris!

Stereospecific functionalizations and transformations of secondary and tertiary boronic esters

Bristol Synthesis Meeting

April 2017
Bristol Synthesis Meeting

On 4 April, Bristol hosted its 17th Synthesis Meeting. We had five fantastic talks that proved chemistry is vibrant like never before. From total synthesis to methodology to bioengineering - one can make great discoveries everywhere. We want to thank all attendees, our sponsors, and of course the five incredibly inspirational speakers!

Bristol Synthesis Meeting 2017

Updated Research Page

March 2017
Aggarwal Group Research

Please welcome our new and shiny Research page! With almost a dozen of detailed schemes, plus direct references, it is much more complete than the previous version.

Aggarwal Group Research

Registration for Bristol Synthesis Meeting

March 2017
Bristol Synthesis Meeting

The registration is now open for the Bristol Synthesis Meeting! We are glad to announce the following line-up of speakers:

  • Professor Thomas R. Hoye (University of Minnesota)
  • Professor Nicholas Turner (University of Manchester)
  • Professor Erik J. Sorensen (Princeton University)
  • Professor Ivan Huc (University of Bordeaux)
  • Professor M. Christina White (University of Illinois)

Please visit the event page on the School of Chemistry website for further information.

Dr. Yahui Wang Leaves the Lab

February 2017
Yahui Wang

Dr. Yahui Wang has left the lab. He is moving to China where he will become a professor at the Institute of Advanced Synthesis, Nanjing Tech University. We wish you the most spectacular career, Yahui!

Selective Uni- and Bidirectional Homologation of Diborylmethane

February 2017
Chemical Science

The group has published a paper in Chemical Science on mono- and bidirectional homologation of diborylmethane. Congrats to Daniel, Damiano, Joe, and Helen!

Abstract

Muhammad Imran Starts

January 2017
Muhammad Imran

Dr. Muhammad Imran has joined the lab. Welcome to Aggarwal group, Imran!

Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans

January 2017
Angewandte Chemie International Edition

Our work on three-component trifluoromethylation/alkylation of furans has been published in ACIE (thus making it two group's papers in the same issue). Congrats to Yahui, Adam and Chris!

Abstract

Stereocontrolled Total Synthesis of (−)-Stemaphylline

January 2017
Angewandte Chemie International Edition

Our group has published total synthesis of (−)-Stemaphylline. The work features several lithiation-borylation reactions, inluding a late-stage lithiation–borylation with a tertiary amine containing carbenoid. Congrats to Ana and Lennart!

Abstract

New Website

23 December 2016
Aggarwal Group New Website

Our group has a shiny new website! Check out our new guides: the power of lithiation-borylation, practical guides, and recommendation on buying sparteine.

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Lorenz Leaving

December 2016
Lorenz E. Löffler

Lorenz Loffler, a visiting undergraduate student, has finished his placement and left for Germany. We wish Lorenz success in his PhD application and future career. You have been a fantastic student and made a really valuable contribution to the project.

PhD viva for Christopher Brown

December 2016
Christopher Brown

Chris has successfully defended his PhD thesis and is now Dr. Christopher Brown. Congrats, Chris!

Stereodivergent Olefination of Enantioenriched Boronic Esters

December 2016
Angewandte Chemie International Edition

Roly and Cristina have published a paper in ACIE on their work on stereodivergent olefination of enantioenriched boronic esters. Congrats!

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Prize for Christopher Sandford

December 2016
Christopher Sandford

Chris was awarded second prize in the poster competition at the Late Stage Functionalization for Synthesis and Medicines Symposium, held at the University of Oxford.

Prize for Ana Varela

December 2016
Ana Varela

Ana won a runner-up prize at the recent Royal Society of Chemistry’s Organic Division Poster Symposium. This is competitive event at which just 40 posters were presented, selected out of 117 applications from across the UK.

Poster Presentation Award for Lydia Dewis

December 2016
Lydia Dewis

Lydia won the ChemMedChem Poster Presentation Award for her poster entitled ‘Conformationally Controlled Hydrocarbons as Scaffolds for Inhibitors of Protein–Protein Interactions’ at the recent Protein-Protein Interactions 2016 conference in London organised by the SCI and RSC.

Poster Prize for Dr. Yahui Wang

December 2016
Yahui Wang

Yahui won a poster prize for his work entitled 'Enantiospecific Alkynylation of Alkylboronic Esters & Three Component Coupling of Boronic Esters with Furans Triggered by Trifluoromethylation' at the International Conference on New Challenges in Organic Synthesis held at Guangzhou in China last week.

Dr. Marcin Odachowski

December 2016
Marcin Odachowski

Marcin has successfully passed his PhD viva and now he is Dr. Marcin Odachowski. Congrats, Marcin!

Humboldt Research Award for Prof. Aggarwal

November 2016
Varinder Aggarwal

Varinder has been elected to receive a Research Award of the Alexander von Humboldt Foundation in recognition of his academic achievements. These are highly prestigious Awards from Germany and are ‘…granted in recognition of a researcher's entire achievements to date to academics whose fundamental discoveries, new theories, or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge achievements in the future’.

Dr. Isabel Perez-Powell

November 2016
Isabel Perez-Powell

Izzy has successfully passed her PhD viva and now she is Dr. Isabel Perez-Powell. Congrats, Izzy!

Total Synthesis of Tatanan A

November 2016
Angewandte Chemie International Edition

Adam Noble and Stefan Roesner have published in Angewandte Chemie on the total synthesis of tatanan A. The paper describes a short and highly stereoselective total synthesis of the sesquilignan natural product tatanan A, and its C-3 epimer using an assembly-line synthesis approach to install the three contiguous stereocenters with high enantio- and diastereoselectivity. Congrats to Adam and Stefan!
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Damon Runyon Fellowship for Daniel Blair

November 2016
Daniel Blair

Daniel Blair, our former PhD student now working as postdoc at the University of Illinois at Urbana-Champaign, has been awarded a prestigious Damon Runyon Fellowship. These highly competitive fellowships offer four years of postdoctoral research funding and are widely recognised as amongst the most prestigious postdoctoral fellowships at the chemistry/biomedical interface in the USA. Congrats, Daniel!

New paper in Angew. Chem. Int. Ed.

October 2016
Angewandte Chemie International Edition

The group has published a paper on regio- and stereoselective homologation of 1,2-bis(boronic esters). The methodology allows to prepare 1,3-diols with impressive levels of stereocontrol (>95:5 d.r.) and is amenable to gram-scale synthesis. A natural product Sch725674 was prepared in 9 steps (LLS). Congrats to Alex, Dominik, Muhammad, and Joe!
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Ella Kriemen to start at ARLANXEO

September 2016
Ella Kriemen

Dr. Ella Kriemen has moved to Germany to join ARLANXEO as Head of Laboratory. Congratulations to Ella!

RSC Teacher Training Scholarship for Isabel Perez-Powell

September 2016

Congratulations to Izzy on winning RSC Teacher Training Scholarship for the academic year of 2016/2017. The scholarship – run in partnership with the Department of Education – includes a £25,000 bursary, free classroom materials, mentoring by an experienced teacher and free online CPD courses.
It is a very competitive process, awarded to those with an excellent understanding of chemistry at school level, a passion for chemistry, teaching, and the empathy, respect and humility needed to relate well to pupils.
During the rigorous selection process, Isabel had to complete an online application before being invited for an intensive interview.
Isabel intends to take up her scholarship when she starts her PGCE training in September 2016. She will train through the INSPIRE programme at Imperial College London. INSPIRE is designed to bridge the gap between STEM research and school science by recruiting able researchers who are good communicators.

New PhD students

September 2016
Riccardo MegaSteven Bennett

Riccardo Mega and Steven Bennett has joined the lab as first-year PhD students. We wish them the most fruitful and enriching research experience!