Aggarwal Group

Recent news

ACIE Review: Asymmetric Synthesis of Secondary and Tertiary Boronic Esters

August 2017
Angew. Chem. Int. Ed.

We have published a review in Angew. Chem. Int. Ed. on the asymmetric synthesis of secondary and tertiary boronic esters. Cognrats to Beatrice and Claire!

Asymmetric Synthesis of Secondary and Tertiary Boronic Esters

JACS: Homologation using Sulfinyl Benzoates

August 2017
J. Am. Chem. Soc.

We have published a JACS paper on homologation of boronic esters using α-sulfinyl benzoates via Li and Mg carbenoids. Congrats to Giorgia, Murat, James, and Matt!

α-Sulfinyl Benzoates as Precursors to Li and Mg Carbenoids for the Stereoselective Iterative Homologation of Boronic Esters

Renata Calo Lapido Starts

August 2017
Renata Calo Lapido

Renata Calo Lapido, a PhD student from the CIQUS, University of Santiago de Compostela, has joined our lab as a visitor. Welcome to the group, Renata!

Elliott Denton Starts

August 2017
Elliott Denton

Elliott Denton, a MSc by Research postgraduate student has joined the group. Welcome to the group, Elliott!

Nandakumar Meganathan Starts

August 2017
Nandakumar Meganathan

Dr. Nandakumar Meganathan, a postdoctoral researcher from India, has joined our lab as a Marie Curie Fellow. Welcome to the group, Nandakumar!

ACIE: Synthesis of Tertiary Alcohols and Thiols

August 2017
Angewandte Chemie International Edition

We have published a paper in Angew. Chem. Int. Ed. on the synthesis of tertiary alcohols and thiols using non-stabilized tertiary α-oxy- and α-thio-organolithiums. Congrats to Alex, Ana, Cinzia and Pradip!

Asymmetric Synthesis of Tertiary Alcohols and Thiols via Non-Stabilized Tertiary α-Oxy- and α-Thio-Organolithiums

Dr. Worawat Niwetmarin

1 August 2017
Worawat Niwetmarin

Worawat Niwetmarin has successfully defended his thesis and became Dr. Niwetmarin. Congrats, Shake!

Dr. Christopher Sandford

31 June 2017
Christopher Sandford

Christopher Sandford has successfully passed his viva and became Dr. Sandford. Congrats, Chris!

Daniel Pflästerer Leaves the Lab

June 2017
Daniel Pflästerer

Dr. Daniel Pflästerer has finished his postdoctoral stay in our lab and returned to Germany. All the best, Daniel!

Nature: Synthesis of Baulamycin

July 2017
Nature

We have published in Nature on the total synthesis of baulamycin. This long and arduous project required a synergy of organic synthesis, molecular modelling and NMR studies as almost all stereocentres in the target had to be reassigned. Congrats to Jingjing, Paula, Siying, and Muhammad!
News & Views
Highlighted in C&EN
Highlighted on Phys.org
Highlighted at the University website
Highlighted in Chemistry World

Synergy of synthesis, computation and NMR reveals correct baulamycin structures

Synthesis: Review on Zweifel Olefination

July 2017
Synthesis

Our latest review has been published in Synthesis. It provides an overview of the Zweifel olefination reaction, from its origins to the most recent developments. Congrats, Roly!

50 Years of Zweifel Olefination: A Transition-Metal-Free Coupling

JACS: Markovnikov Hydroboration of Unactivated Terminal Alkenes

June 2017
J. Am. Chem. Soc.

We have published in JACS on enantioselective rhodium(III)-catalyzed Markovnikov hydroboration of unactivated terminal alkenes. This is our second JACS paper in one week! Congrats to James, Beatrice and Matt!

Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes

JACS: Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters

June 2017
J. Am. Chem. Soc.

We have published a JACS paper on enantiospecific synthesis of ortho-substituted benzylic boronic esters by a 1,2-metalate rearrangement/1,3-borotropic shift sequence. Congrats to Stefan and Rafael!

Enantiospecific Synthesis of ortho-Substituted Benzylic Boronic Esters by a 1,2-Metalate Rearrangement/1,3-Borotropic Shift Sequence

Highlighted in Angew. Chem. Int. Ed.

June 2017
Angewandte Chemie International Edition

Our JACS publication on photochemical alkylation of vinyl boronate complexes has been highlighted in the coming Angew. Chem. Int. Ed. issue. Congrats to Mattia and Chris!

ACIE: Enantiospecific sp2-sp3 Coupling

June 2017
Angewandte Chemie International Edition

Our paper on enantiospecific sp2-sp3 coupling of boronic esters with p-arylacetylenes has been accepted in Angew. Chem. Int. Ed. Congratulations, Ganesh and Marcin!

Alkynyl Moiety for Triggering 1,2-Metallate Shifts: Enantiospecific sp2-sp3 Coupling of Boronic Esters with p-Arylacetylenes

Rafael Dias Starts

June 2017
Rafael Dias

Rafael Dias, a postdoctoral researcher from Brasil, has joined our lab. Welcome to the group, Rafael!

Thesis Commendation for Maziar Mohiti

June 2017
Maziar Mohiti

PhD thesis of Maziar Mohiti (2011–2015) has been commended by the Faculty of Science of the University of Bristol. This accolade is achieved by only about 10% of the research students. Congrats, Maziar!

Tobias Biberger Leaves the Lab

June 2017
Tobias Biberger

Tobias Biberger, a visiting student from Germany, has finished his placement in Aggarwal Group and is now back in Aachen, where he will continue his Master's studies. We thank Tobias for all the hard work and lots of fun he brought. All the best, Tobias!

Science: Photoinduced Decarboxylative Borylation

June 2017
Science

We have just published our paper on the photoinduced decarboxylative borylation of carboxylic acids in Science (First Release). This new methodology links the diversity of carboxylic acids to the broad utility of boronic esters. Congratulations to Alex, Johan, Yahui and Tatsuya!

Photoinduced Decarboxylative Borylation

Prize for Alex Fawcett

June 2017
Alex Fawcett

Alex Fawcett has won a runner-up prize at the Organic and Biological Section Postgraduate Symposium held at the School of Chemistry. Congrats, Alex!

Rory Mykura Starts

May 2017
Rory Mykura

Rory Mykura, a PhD student from the CDT programme, has joined Aggarwal group. Welcome to the lab, Rory!

Another Poster Prize for Siying Zhong

May 2017
Siying Zhong

Siying Zhong won yet another poster prize! Her poster Synergy of Computation, NMR and Synthesis Reveals True Baulamycin Structure won the 1st place at the inaugural Bio-Techne Chemistry Poster Symposium. The competition included contestants from Bath, Bristol and Cardiff Universities. Impressive achievement, Siying!

Dr. Teerawut Bootwicha leaves the lab

May 2017
Teerawut Tong Bootwicha

Dr. Teerawut "Tong" Bootwicha has left the lab for Thailand where he will start as Lecturer at the Mahidol University (Bangkok). We wish you a spectacular academic career, Tong! Congrats!

Lab Leavers

May 2017

We would like to send our best wishes to the lab's recent alumni: Olivier Wagnières, Paula Lorenzo, and Ana Varela. Olivier is back to Switzerland where he joined a startup in Basel. Paula is back to Spain where she is doing a postdoc with Prof. Ángel R. de Lera and Prof. Rosana Álvarez (University of Vigo). And Ana joined the Institute of Cancer Research in London as a postdoc. Great job, everyone!

Dr. Ana Varela

19 May 2017
Ana Varela

Congratulations to Ana on successfully passing her viva and becoming Dr. Varela!

On the Cover of Chemical Communications

May 2017
Chemical Communications

Our review on the sterospecific functionalizations of boronic esters has been selected for the inside cover of Chemical Communications, Issue 40. The cover, entitled "Boron at the helm", features a famous steamship SS Great Britain, one of Bristol landmarks. Congrats to Chris!

Chemical Communications

RSC Synthetic Organic Chemistry Award for Prof. Aggarwal

May 2017
Varinder Aggarwal

Varinder has been awarded the Royal Society of Chemistry Synthetic Organic Chemistry Award for 2017. This has been given for "highly creative work in the development of new synthetic methods based on the asymmetric homologation of boronic esters and their applications in natural and non-natural product synthesis".

As part of the Award, Varinder will deliver a number of lectures across UK universities.

Poster Prize for Siying Zhong

April 2017
Siying Zhong

Second year PhD student Siying Zhong won the 1st prize at the annual Organic and Biological Section Syngenta Poster Competition for postgraduate students. Her poster was titled Synergy of Computation, NMR and Synthesis Reveals True Baulamycin Structure. Contrats, Siying!

Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling

April 2017
Org. Lett.

Our paper on the synthesis of alkenes by the transition-metal-free Zweifel couplig is out. Congratulations to Roly and Shake!

Synthesis of Functionalized Alkenes by a Transition-Metal-Free Zweifel Coupling

Conjunctive Functionalization of Vinyl Boronate Complexes

April 2017
Chemical Communications

We have published a paper on functionalisation of vinyl boronates into useful products, using a diastereoselective three-component coupling. Congrats to Roly, Chris, and Cristina!

Conjunctive functionalization of vinyl boronate complexes with electrophiles: a diastereoselective three-component coupling

Merging Photoredox with 1,2-Metallate Rearrangements

April 2017
J. Am. Chem. Soc.

We have published a JACS paper on photochemical alkylation of vinyl boronate complexes. Congrats to Mattia and Chris!

Merging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes

Stereoselective Synthesis of Polypropionates

April 2017
Nature Chemistry

Our Nature Chemistry paper on the application of assembly-line synthesis towards polypropionates is out! Congrats to Tong and Julian!

Iterative assembly line synthesis of polypropionates with full stereocontrol

Review on Boron Functionalization

April 2017
Chemical Communications

Our group has published a feature article in Chemical Communications on stereospecific functionalizations and transformations of secondary and tertiary boronic esters. Congrats, Chris!

Stereospecific functionalizations and transformations of secondary and tertiary boronic esters

Bristol Synthesis Meeting

April 2017
Bristol Synthesis Meeting

On 4 April, Bristol hosted its 17th Synthesis Meeting. We had five fantastic talks that proved chemistry is vibrant like never before. From total synthesis to methodology to bioengineering - one can make great discoveries everywhere. We want to thank all attendees, our sponsors, and of course the five incredibly inspirational speakers!

Bristol Synthesis Meeting 2017

Updated Research Page

March 2017
Aggarwal Group Research

Please welcome our new and shiny Research page! With almost a dozen of detailed schemes, plus direct references, it is much more complete than the previous version.

Aggarwal Group Research

Registration for Bristol Synthesis Meeting

March 2017
Bristol Synthesis Meeting

The registration is now open for the Bristol Synthesis Meeting! We are glad to announce the following line-up of speakers:

  • Professor Thomas R. Hoye (University of Minnesota)
  • Professor Nicholas Turner (University of Manchester)
  • Professor Erik J. Sorensen (Princeton University)
  • Professor Ivan Huc (University of Bordeaux)
  • Professor M. Christina White (University of Illinois)

Please visit the event page on the School of Chemistry website for further information.

Dr. Yahui Wang Leaves the Lab

February 2017
Yahui Wang

Dr. Yahui Wang has left the lab. He is moving to China where he will become a professor at the Institute of Advanced Synthesis, Nanjing Tech University. We wish you the most spectacular career, Yahui!

Selective Uni- and Bidirectional Homologation of Diborylmethane

February 2017
Chemical Science

The group has published a paper in Chemical Science on mono- and bidirectional homologation of diborylmethane. Congrats to Daniel, Damiano, Joe, and Helen!

Abstract

Muhammad Imran Starts

January 2017
Muhammad Imran

Dr. Muhammad Imran has joined the lab. Welcome to Aggarwal group, Imran!

Enantiospecific Trifluoromethyl-Radical-Induced Three-Component Coupling of Boronic Esters with Furans

January 2017
Angewandte Chemie International Edition

Our work on three-component trifluoromethylation/alkylation of furans has been published in ACIE (thus making it two group's papers in the same issue). Congrats to Yahui, Adam and Chris!

Abstract

Stereocontrolled Total Synthesis of (−)-Stemaphylline

January 2017
Angewandte Chemie International Edition

Our group has published total synthesis of (−)-Stemaphylline. The work features several lithiation-borylation reactions, inluding a late-stage lithiation–borylation with a tertiary amine containing carbenoid. Congrats to Ana and Lennart!

Abstract

New Website

23 December 2016
Aggarwal Group New Website

Our group has a shiny new website! Check out our new guides: the power of lithiation-borylation, practical guides, and recommendation on buying sparteine.

Abstract

Lorenz Leaving

December 2016
Lorenz E. Löffler

Lorenz Loffler, a visiting undergraduate student, has finished his placement and left for Germany. We wish Lorenz success in his PhD application and future career. You have been a fantastic student and made a really valuable contribution to the project.

PhD viva for Christopher Brown

December 2016
Christopher Brown

Chris has successfully defended his PhD thesis and is now Dr. Christopher Brown. Congrats, Chris!

Stereodivergent Olefination of Enantioenriched Boronic Esters

December 2016
Angewandte Chemie International Edition

Roly and Cristina have published a paper in ACIE on their work on stereodivergent olefination of enantioenriched boronic esters. Congrats!

Abstract

Prize for Christopher Sandford

December 2016
Christopher Sandford

Chris was awarded second prize in the poster competition at the Late Stage Functionalization for Synthesis and Medicines Symposium, held at the University of Oxford.

Prize for Ana Varela

December 2016
Ana Varela

Ana won a runner-up prize at the recent Royal Society of Chemistry’s Organic Division Poster Symposium. This is competitive event at which just 40 posters were presented, selected out of 117 applications from across the UK.

Poster Presentation Award for Lydia Dewis

December 2016
Lydia Dewis

Lydia won the ChemMedChem Poster Presentation Award for her poster entitled ‘Conformationally Controlled Hydrocarbons as Scaffolds for Inhibitors of Protein–Protein Interactions’ at the recent Protein-Protein Interactions 2016 conference in London organised by the SCI and RSC.

Poster Prize for Dr. Yahui Wang

December 2016
Yahui Wang

Yahui won a poster prize for his work entitled 'Enantiospecific Alkynylation of Alkylboronic Esters & Three Component Coupling of Boronic Esters with Furans Triggered by Trifluoromethylation' at the International Conference on New Challenges in Organic Synthesis held at Guangzhou in China last week.

Dr. Marcin Odachowski

December 2016
Marcin Odachowski

Marcin has successfully passed his PhD viva and now he is Dr. Marcin Odachowski. Congrats, Marcin!

Humboldt Research Award for Prof. Aggarwal

November 2016
Varinder Aggarwal

Varinder has been elected to receive a Research Award of the Alexander von Humboldt Foundation in recognition of his academic achievements. These are highly prestigious Awards from Germany and are ‘…granted in recognition of a researcher's entire achievements to date to academics whose fundamental discoveries, new theories, or insights have had a significant impact on their own discipline and who are expected to continue producing cutting-edge achievements in the future’.

Dr. Isabel Perez-Powell

November 2016
Isabel Perez-Powell

Izzy has successfully passed her PhD viva and now she is Dr. Isabel Perez-Powell. Congrats, Izzy!

Total Synthesis of Tatanan A

November 2016
Angewandte Chemie International Edition

Adam Noble and Stefan Roesner have published in Angewandte Chemie on the total synthesis of tatanan A. The paper describes a short and highly stereoselective total synthesis of the sesquilignan natural product tatanan A, and its C-3 epimer using an assembly-line synthesis approach to install the three contiguous stereocenters with high enantio- and diastereoselectivity. Congrats to Adam and Stefan!
Abstract

Damon Runyon Fellowship for Daniel Blair

November 2016
Daniel Blair

Daniel Blair, our former PhD student now working as postdoc at the University of Illinois at Urbana-Champaign, has been awarded a prestigious Damon Runyon Fellowship. These highly competitive fellowships offer four years of postdoctoral research funding and are widely recognised as amongst the most prestigious postdoctoral fellowships at the chemistry/biomedical interface in the USA. Congrats, Daniel!

New paper in Angew. Chem. Int. Ed.

October 2016
Angewandte Chemie International Edition

The group has published a paper on regio- and stereoselective homologation of 1,2-bis(boronic esters). The methodology allows to prepare 1,3-diols with impressive levels of stereocontrol (>95:5 d.r.) and is amenable to gram-scale synthesis. A natural product Sch725674 was prepared in 9 steps (LLS). Congrats to Alex, Dominik, Muhammad, and Joe!
Abstract

Ella Kriemen to start at ARLANXEO

September 2016
Ella Kriemen

Dr. Ella Kriemen has moved to Germany to join ARLANXEO as Head of Laboratory. Congratulations to Ella!

RSC Teacher Training Scholarship for Isabel Perez-Powell

September 2016

Congratulations to Izzy on winning RSC Teacher Training Scholarship for the academic year of 2016/2017. The scholarship – run in partnership with the Department of Education – includes a £25,000 bursary, free classroom materials, mentoring by an experienced teacher and free online CPD courses.
It is a very competitive process, awarded to those with an excellent understanding of chemistry at school level, a passion for chemistry, teaching, and the empathy, respect and humility needed to relate well to pupils.
During the rigorous selection process, Isabel had to complete an online application before being invited for an intensive interview.
Isabel intends to take up her scholarship when she starts her PGCE training in September 2016. She will train through the INSPIRE programme at Imperial College London. INSPIRE is designed to bridge the gap between STEM research and school science by recruiting able researchers who are good communicators.

New PhD students

September 2016
Riccardo MegaSteven Bennett

Riccardo Mega and Steven Bennett has joined the lab as first-year PhD students. We wish them the most fruitful and enriching research experience!

Adolf Lieben Lectureship for Prof. Aggarwal

August 2016
Varinder Aggarwal

Varinder has been selected to be the Adolf Lieben Lecturer for 2017. This lectureship requires him to tour Austria and give lectures at the universities of Innsbruck, Linz, Vienna and Graz which he will do next year.

Christopher Brown starts at Charles River

August 2016
Christopher Brown

Chris Brown has joined Charles River company. Congratulations to Chris!

Daniel Blair starts postdoc with Martin Burke

August 2016
Daniel Blair

Dr. Daniel Blair started his postdoc with Prof. Martin Burke at the University of Illinois, Urbana-Champaign. Congrats, Daniel!

Damien Mailhol to start at Evotec

July 2016
Damien Mailhol

Dr. Damien Mailhol has moved to France to join the Evotec company as a senior scientist. Congratulations, Damien!

Prof. Aggarwal to give Novartis Lecture

June 2016
Varinder Aggarwal

Varinder has been invited to deliver the inaugural Novartis Lecture at the University of Toronto in April next year.

Welcome to Lorenz Loffler

June 2016
Lorenz E. Löffler

Lorenz Loffler, a visiting undergraduate student from Germany, has joined the lab for a 6 month project. He will work together with Dr. Oleksandr Zhurakovskyi on a total synthesis of an indole alkaloid.

Another Gilbert Stork Lectureship for Prof. Aggarwal

June 2016
Varinder Aggarwal

Varinder has been invited to be the 2016-17 Gilbert Stork Lecturer at the University of Wisconsin-Madison. This is a prestigious endowed Lectureship to ‘help energize the subject of organic chemistry’ established by famous organic chemist Gilbert Stork at the institution where he did his PhD. There is a second endowed Gilbert Stork Lectureship at the University of Pennsylvania which Varinder was invited to give earlier this year.

Academic positions for two lab members

May 2016
Yahui Wang
Jack Chen

Congratulations to the following post-docs who have recently secured academic positions:
– Yahui Wang, Institute of Advanced Synthesis, Nanjing Tech University, Nanjing, China
– Jack Chen, School of Applied Sciences, Auckland University of Technology, Auckland, NZ

Runner-up prize for Ana Varela

April 2016
Ana Varela

Ana Varela, a 3rd year PhD student, received a runner-up prize at the 7th SCI Postgraduate Symposium on Novel Organic Chemistry, South division. The Symposium took place on 19 April at Imperial College, London.

Marcin Odachowski starts a postdoc

April 2016
Marcin Odachowski

Marcin Odachowski has joined Nick Turner's lab as a postdoc. Congrats, Marcin!

Award for Chris Brown

March 2016
Chris Brown

Chris Brown, a 4th year PhD student, attended the 13th EuCheMS Chemistry Conference for Young Scientists in Belgium on 16-18 March and won the 1st prize in the Organic section with his talk entitled ‘Synthesis of the Mycolactone Core Through Lithiation-Borylation Methodology’.

Gilbert Stork Lectureship for Prof. Aggarwal

January 2016
Varinder Aggarwal

Varinder has been invited to be the third recipient of the Gilbert Stork Lectureship in Organic Chemistry in the Department of Chemistry at the University of Pennsylvania. This is a prestigious endowed lectureship established to ‘help energize the subject of organic chemistry’. Varinder will give the lecture in the spring of 2017.

Synfact of the Month

December 2015
Synfacts

Our article on the synthesis of six- and seven-membered heterocycles (Org. Lett., 2015, 17, 5044) has been selected as a Synfact of the Month. Congratulations, Johnathan Matlock, Thomas Svejstrup, Pradip Songara, Sarah Overington, and Eoghan M. McGarrigle!
More details.